| Tag | Content |
|---|
| CPLM ID | CPLM-005804 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Elongation factor 1-delta |
Protein Synonyms/Alias | EF-1-delta; Antigen NY-CO-4 |
Gene Name | EEF1D |
Gene Synonyms/Alias | EF1D |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 376 | TNFLAHEKIWFDKFK | ubiquitination | [1] | | 381 | HEKIWFDKFKYDDAE | ubiquitination | [1] | | 425 | RARENIQKSLAGSSG | ubiquitination | [1, 2] | | 473 | ELQQAISKLEARLNV | ubiquitination | [1, 2] | | 483 | ARLNVLEKSSPGHRA | ubiquitination | [2] | | 598 | GLVWGASKLVPVGYG | ubiquitination | [1, 2] |
|
Reference | [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome. |
Sequence Annotation | REGION 80 115 Leucine-zipper.
REGION 173 281 Catalytic (GEF).
MOD_RES 2 2 N-acetylalanine.
MOD_RES 17 17 N6-acetyllysine.
MOD_RES 107 107 N6-acetyllysine.
MOD_RES 117 117 N6-acetyllysine.
MOD_RES 129 129 Phosphothreonine (By similarity).
MOD_RES 133 133 Phosphoserine.
MOD_RES 147 147 Phosphothreonine.
MOD_RES 162 162 Phosphoserine; by CK2. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; DNA-binding; Elongation factor; Nucleus; Phosphoprotein; Protein biosynthesis; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 281 AA |
Protein Sequence | MRSGKASCTL ETVWEDKHKY EEAERRFYEH EATQAAASAQ QLPAEGPAMN GPGQDDPEDA 60
DEAEAPDGGS RRDPRKSQDS RKPLQKKRKR SPKSGLGPAD LALLGLSAER VWLDKSLFDQ 120
AESSYRQKLA DVAAQAAWPP ALAPWGLCTH GNQVACHHVT WGIWVNKSSF DQAERAFVEW 180
SQALLLAPDG SRRQGTPNTG QQVAVPDLAH QPSPPVNGQP PLGSLQALVR EVWLEKPRYD 240
AAERGFYEAL FDGHPPGKVR LQERAGLAEG ARRGRRDRRG RNILGNKRAG LRRADGEAPS 300
ALPYCYFLQK DAEAPWLSKP AYDSAECRHH AAEALRVAWC LEAASLSHRP GPRSGLSVSS 360
LRPNRKMATN FLAHEKIWFD KFKYDDAERR FYEQMNGPVA GASRQENGAS VILRDIARAR 420
ENIQKSLAGS SGPGASSGTS GDHGELVVRI ASLEVENQSL RGVVQELQQA ISKLEARLNV 480
LEKSSPGHRA TAPQTQHVSP MRQVEPPAKK PATPAEDDED DDIDLFGSDN EEEDKEAAQL 540
REERLRQYAE KKAKKPALVA KSSILLDVKP WDDETDMAQL EACVRSIQLD GLVWGASKLV 600
PVGYGIRKLQ IQCVVEDDKV GTDLLEEEIT KFEEHVQSVD IAAFNKI 647 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005853; C:eukaryotic translation elongation factor 1 complex; TAS:ProtInc. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0004871; F:signal transducer activity; IMP:UniProtKB. GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW. GO:0008135; F:translation factor activity, nucleic acid binding; TAS:ProtInc. GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006414; P:translational elongation; TAS:Reactome. |
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