CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023726
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein MTO1 homolog, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 MTO1 
Gene Synonyms/Alias
 CGI-02 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
227GLAQTLEKLGFVVGRubiquitination[1]
372IRGLEKAKVIQPGYGubiquitination[1, 2]
519EEGISVLKSIEFLSSubiquitination[1]
527SIEFLSSKWKKLIPEubiquitination[1]
552VRALDVLKYEEVDMDubiquitination[1]
612DEALQLPKDLDYLTIubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. 
Sequence Annotation
 NP_BIND 43 48 FAD (By similarity).  
Keyword
 Alternative splicing; Cardiomyopathy; Complete proteome; Disease mutation; FAD; Flavoprotein; Mitochondrion; Reference proteome; Transit peptide; tRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 717 AA 
Protein Sequence
MFYFRGCGRW VAVSFTKQQF PLARLSSDSA APRTPHFDVI VIGGGHAGTE AATAAARCGS 60
RTLLLTHRVD TIGQMSCNPS FGGIGKGHLM REVDALDGLC SRICDQSGVH YKVLNRRKGP 120
AVWGLRAQID RKLYKQNMQK EILNTPLLTV QEGAVEDLIL TEPEPEHTGK CRVSGVVLVD 180
GSTVYAESVI LTTGTFLRGM IVIGLETHPA GRLGDQPSIG LAQTLEKLGF VVGRLKTGTP 240
PRIAKESINF SILNKHIPDN PSIPFSFTNE TVWIKPEDQL PCYLTHTNPR VDEIVLKNLH 300
LNSHVKETTR GPRYCPSIES KVLRFPNRLH QVWLEPEGMD SDLIYPQGLS MTLPAELQEK 360
MITCIRGLEK AKVIQPGYGV QYDYLDPRQI TPSLETHLVQ RLFFAGQING TTGYEEAAAQ 420
GVIAGINASL RVSRKPPFVV SRTEGYIGVL IDDLTTLGTS EPYRMFTSRV EFRLSLRPDN 480
ADSRLTLRGY KDAGCVSQQR YERACWMKSS LEEGISVLKS IEFLSSKWKK LIPEASISTS 540
RSLPVRALDV LKYEEVDMDS LAKAVPEPLK KYTKCRELAE RLKIEATYES VLFHQLQEIK 600
GVQQDEALQL PKDLDYLTIR DVSLSHEVRE KLHFSRPQTI GAASRIPGVT PAAIINLLRF 660
VKTTQRRQSA MNESSKTDQY LCDADRLQER EL 692 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0070899; P:mitochondrial tRNA wobble uridine modification; IEA:Compara.
 GO:0055114; P:oxidation-reduction process; IEA:InterPro. 
Interpro
 IPR013027; FAD_pyr_nucl-diS_OxRdtase.
 IPR026904; GidA-assoc_3.
 IPR002218; GIDA-rel.
 IPR020595; GIDA-rel_CS. 
Pfam
 PF01134; GIDA
 PF13932; GIDA_assoc_3 
SMART
  
PROSITE
 PS01280; GIDA_1
 PS01281; GIDA_2 
PRINTS
 PR00368; FADPNR.