CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040580
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein polybromo-1 
Protein Synonyms/Alias
  
Gene Name
 Pbrm1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
606EGMMEDMKLMFRNARubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Bromodomain; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1704 AA 
Protein Sequence
MGSKRRRATS PSSSVSGDFD DGHHSVPTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY 60
KDEQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK LKMEEYDDVN LLTADFQLLF 120
NNAKAYYKPD SPEYKAACKL WDLYLRTRNE FVQKGEADDE DDDEDGQDNQ GTLADGSSPG 180
YLKEILEQLL EAIVVATNPS GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG 240
SYKSIHAMAK DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMTKSSLRIR 300
TASNLAAARL TGPSHNKSSL GEERNPTSKY YRNKRAVQGG RLSAITMALQ YGSESEEDAA 360
LAAARYEEGE SEAESITSFM DVSNPFHQLY DTVRSCRNHQ GQLIAEPFFH LPSKKKYPDY 420
YQQIKMPISL QQIRTKLKNQ EYETLDHLEC DLNLMFENAK RYNVPNSAIY KRVLKLQQVM 480
QAKKKELARR DDIEDGDSMI SSATSDTGSA KRKRNTHDSE MLGLRRLSSK KNIRKQRMKI 540
LFNVVLEARE PGSGRRLCDL FMVKPSKKDY PDYYKIILEP MDLKIIEHNI RNDKYAGEEG 600
MMEDMKLMFR NARHYNEEGS QVYNDAHILE KLLKDKRKEL GPLPDDDDMA SPKLKLSRKS 660
GVSPKKSKYM TPMQQKLNEV YEAVKNYTDK RGRRLSAIFL RLPSRSELPD YYLTIKKPMD 720
MEKIRSHMMA NKYQDIDSMV EDFVMMFNNA CTYNEPESLI YKDALVLHKV LLETRRDLEG 780
DEDSHVPNVT LLIQELIHNL FVSVMSHQDD EGRCYSDSLA EIPAVDPNSP NKPPLTFDII 840
RKNVESNRYR RLDLFQEHMF EVLERARRMN RTDSEIYEDA VELQQFFIRI RDELCKNGEI 900
LLSPALSYTT KHLHNDVEKE KKEKLPKEIE EDKLKREEEK REAEKSEDSS GTTGLSGLHR 960
TYSQDCSFKN SMYHVGDYVY VEPAEANLQP HIVCIERLWE DSAGEKWLYG CWFYRPNETF 1020
HLATRKFLEK EVFKSDYYNK VPVSKILGKC VVMFVKEYFK LCPENFRDED VFVCESRYSA 1080
KTKSFKKIKL WTMPISSVRF VPRDVPLPVV RVASVFANAD KGDDEKNTDN SDDNRAEDNF 1140
NLEKEKEDVP VEMSNGEPGC HYFEQLRYND MWLKVGDCVF IKSHGLVRPR VGRIEKVWVR 1200
DGAAYFYGPI FIHPEETEHE PTKMFYKKEV FLSNLEETCP MSCILGKCAV LSFKDFLSCR 1260
PTEIPENDIL LCESRYNESD KQMKKFKGLK RFSLSAKVVD DEIYYFRKPI IPQKEPSPLL 1320
EKKIQLLEAK FAELEGGDDD IEEMGEEDSE VIEAPSLPQL QTPLANELDL MPYTPPQSTP 1380
KSAKGSAKKE SSKRKINMSG YILFSSEMRA VIKAQHPDYS FGELSRLVGT EWRNLETAKK 1440
AEYEERAAKV AEQQERERAA QQQQPSASPR AGTPVGALMG VVPPPTPMGM LNQQLTPVAG 1500
MMGGYPPGLP PLQGPVDGLV SMGSMQPLHP GGPPPHHLPP GVPGLPGIPP PGVMNQGVAP 1560
MVGTPAPGGS PYGQQVGVLG PPGQQAPPPY PGPHPAGPPV IQQPTTPMFV APPPKTQRLL 1620
HSEAYLKYIE GLSAESNSIS KWDQTLAARR RDVHLSKEQE SRLPSHWLKS KGAHTTMADA 1680
LWRLRDLMLR DTLNIRQAYN LENV 1704 
Gene Ontology
 GO:0000776; C:kinetochore; IDA:MGI.
 GO:0005634; C:nucleus; IC:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0007507; P:heart development; IMP:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0001890; P:placenta development; IMP:MGI. 
Interpro
 IPR001025; BAH_dom.
 IPR001487; Bromodomain.
 IPR018359; Bromodomain_CS.
 IPR009071; HMG_box_dom. 
Pfam
 PF01426; BAH
 PF00439; Bromodomain
 PF00505; HMG_box 
SMART
 SM00439; BAH
 SM00297; BROMO
 SM00398; HMG 
PROSITE
 PS51038; BAH
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2
 PS50118; HMG_BOX_2 
PRINTS
 PR00503; BROMODOMAIN.