CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000437
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fanconi anemia group A protein 
Protein Synonyms/Alias
 Protein FACA 
Gene Name
 FANCA 
Gene Synonyms/Alias
 FAA; FACA; FANCH 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
34AGRVKREKYNPERAQubiquitination[1]
44PERAQKLKESAVRLLubiquitination[2]
70EVEGPLCKKLSLSKVubiquitination[1]
71VEGPLCKKLSLSKVIubiquitination[1]
76CKKLSLSKVIDCDSSubiquitination[1]
249FVLRGFQKNSDLRRTubiquitination[1, 2]
261RRTVEPEKMPQVTVDubiquitination[1, 2]
293QEESSTHKIVRCWFGubiquitination[1]
335LTHSPVLKASDAVQMubiquitination[1, 2]
515TDYISLAKTRLADLKubiquitination[1, 2, 3, 4, 5, 6]
522KTRLADLKVSIENMGubiquitination[2]
608VAFIESLKRADKIPPubiquitination[1, 2]
612ESLKRADKIPPSLYSubiquitination[1]
701DSSVEISKIQLSINTubiquitination[1, 2, 5]
867LSPGLIKKFQFLMFRubiquitination[1]
1079QRELLMYKRILLRLPubiquitination[1, 2]
1162ILAKCQTKCPLILTSubiquitination[1]
1199PLPRELQKLQEGRQFubiquitination[1, 2, 3, 4, 5, 6]
1387AGRSLELKGQGNPVEubiquitination[1, 2, 4, 5]
1398NPVELITKARLFLLQubiquitination[1, 2, 5]
1413LIPRCPKKSFSHVAEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
 DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. 
Sequence Annotation
 MOTIF 18 34 Nuclear localization signal (Potential).
 MOD_RES 1449 1449 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; DNA damage; DNA repair; Fanconi anemia; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1455 AA 
Protein Sequence
MSDSWVPNSA SGQDPGGRRR AWAELLAGRV KREKYNPERA QKLKESAVRL LRSHQDLNAL 60
LLEVEGPLCK KLSLSKVIDC DSSEAYANHS SSFIGSALQD QASRLGVPVG ILSAGMVASS 120
VGQICTAPAE TSHPVLLTVE QRKKLSSLLE FAQYLLAHSM FSRLSFCQEL WKIQSSLLLE 180
AVWHLHVQGI VSLQELLESH PDMHAVGSWL FRNLCCLCEQ MEASCQHADV ARAMLSDFVQ 240
MFVLRGFQKN SDLRRTVEPE KMPQVTVDVL QRMLIFALDA LAAGVQEESS THKIVRCWFG 300
VFSGHTLGSV ISTDPLKRFF SHTLTQILTH SPVLKASDAV QMQREWSFAR THPLLTSLYR 360
RLFVMLSAEE LVGHLQEVLE TQEVHWQRVL SFVSALVVCF PEAQQLLEDW VARLMAQAFE 420
SCQLDSMVTA FLVVRQAALE GPSAFLSYAD WFKASFGSTR GYHGCSKKAL VFLFTFLSEL 480
VPFESPRYLQ VHILHPPLVP GKYRSLLTDY ISLAKTRLAD LKVSIENMGL YEDLSSAGDI 540
TEPHSQALQD VEKAIMVFEH TGNIPVTVME ASIFRRPYYV SHFLPALLTP RVLPKVPDSR 600
VAFIESLKRA DKIPPSLYST YCQACSAAEE KPEDAALGVR AEPNSAEEPL GQLTAALGEL 660
RASMTDPSQR DVISAQVAVI SERLRAVLGH NEDDSSVEIS KIQLSINTPR LEPREHMAVD 720
LLLTSFCQNL MAASSVAPPE RQGPWAALFV RTMCGRVLPA VLTRLCQLLR HQGPSLSAPH 780
VLGLAALAVH LGESRSALPE VDVGPPAPGA GLPVPALFDS LLTCRTRDSL FFCLKFCTAA 840
ISYSLCKFSS QSRDTLCSCL SPGLIKKFQF LMFRLFSEAR QPLSEEDVAS LSWRPLHLPS 900
ADWQRAALSL WTHRTFREVL KEEDVHLTYQ DWLHLELEIQ PEADALSDTE RQDFHQWAIH 960
EHFLPESSAS GGCDGDLQAA CTILVNALMD FHQSSRSYDH SENSDLVFGG RTGNEDIISR 1020
LQEMVADLEL QQDLIVPLGH TPSQEHFLFE IFRRRLQALT SGWSVAASLQ RQRELLMYKR 1080
ILLRLPSSVL CGSSFQAEQP ITARCEQFFH LVNSEMRNFC SHGGALTQDI TAHFFRGLLN 1140
ACLRSRDPSL MVDFILAKCQ TKCPLILTSA LVWWPSLEPV LLCRWRRHCQ SPLPRELQKL 1200
QEGRQFASDF LSPEAASPAP NPDWLSAAAL HFAIQQVREE NIRKQLKKLD CEREELLVFL 1260
FFFSLMGLLS SHLTSNSTTD LPKAFHVCAA ILECLEKRKI SWLALFQLTE SDLRLGRLLL 1320
RVAPDQHTRL LPFAFYSLLS YFHEDAAIRE EAFLHVAVDM YLKLVQLFVA GDTSTVSPPA 1380
GRSLELKGQG NPVELITKAR LFLLQLIPRC PKKSFSHVAE LLADRGDCDP EVSAALQSRQ 1440
QAAPDADLSQ EPHLF 1455 
Gene Ontology
 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0043240; C:Fanconi anaemia nuclear complex; IDA:UniProtKB.
 GO:0006281; P:DNA repair; TAS:Reactome.
 GO:0008585; P:female gonad development; IEA:Compara.
 GO:0008584; P:male gonad development; IEA:Compara.
 GO:0007140; P:male meiosis; IEA:Compara.
 GO:0006461; P:protein complex assembly; TAS:ProtInc.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara. 
Interpro
 IPR003516; Fanconia. 
Pfam
 PF03511; Fanconi_A 
SMART
  
PROSITE
  
PRINTS
 PR00826; FANCONIAGENE.