UniProt Accession

 SUMO4_HUMAN; Q6EEV6; A1L3W5 

Genbank Protein ID

 AY340238; AB205057; AL031133; CH471051; BC130305 

Genbank Nucleotide ID

 AAR04484.1; BAH05006.1; CAA20019.1; EAW47808.1; AAI30306.1 

Protein Name

 Small ubiquitin-related modifier 4 

Protein Synonyms/Alias

 SUMO-4; Small ubiquitin-like protein 4 

Gene Name

 SUMO4 

Gene Synonyms/Alias

 SMT3H4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
11	EKPTEEVKTENNNHI	sumoylation	[1]
21	NNNHINLKVAGQDGS	ubiquitination	[2]

Reference

 [1] A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells.
 Galisson F, Mahrouche L, Courcelles M, Bonneil E, Meloche S, Chelbi-Alix MK, Thibault P.
 Mol Cell Proteomics. 2011 Feb;10(2):M110.004796. [PMID: 21098080]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. 

Sequence Annotation

 DOMAIN 17 95 Ubiquitin-like.
 CROSSLNK 93 93 Glycyl lysine isopeptide (Gly-Lys)  

Keyword

 Complete proteome; Isopeptide bond; Polymorphism; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 95 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0016925; P:protein sumoylation; IEA:InterPro. 

Interpro

 IPR022617; SUMO.
 IPR027218; SUMO_chordates.
 IPR000626; Ubiquitin.
 IPR019955; Ubiquitin_supergroup. 

Pfam

 PF11976; Rad60-SLD 

SMART

 SM00213; UBQ 

PROSITE

 PS50053; UBIQUITIN_2 

PRINTS