| Tag | Content |
|---|
| CPLM ID | CPLM-021761 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Diablo homolog, mitochondrial |
Protein Synonyms/Alias | Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase; Smac |
Gene Name | Diablo |
Gene Synonyms/Alias | Smac |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 212 | KLAEAQTKELHQKAQ | ubiquitination | [1] | | 217 | QTKELHQKAQEVSDE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases (By similarity). |
Sequence Annotation | MOTIF 54 58 IAP-binding (Potential). |
Keyword | Apoptosis; Complete proteome; Mitochondrion; Reference proteome; Transit peptide; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 237 AA |
Protein Sequence | MAALRSWVTR SVCSLFRYRQ RFPVLANSKK RCFSELIKPW HKTVLTGFGM TLCAVPIAQK 60
SEPQSLSNEA LMRRAVSLVT DSTSTFLSQT TYALIEAITE YTKAVYTLVS LYRQYTSLLG 120
KMNSQEEDEV WQVIIGARVE MTSKQQEYLK LETTWMTAVG LSEMAAEAAY QTGADQASIT 180
ARNHIQLVKS QVQEVRQLSQ KAETKLAEAQ TKELHQKAQE VSDEGADQEE EAYLRED 237 |
Gene Ontology | GO:0035631; C:CD40 receptor complex; IDA:BHF-UCL. GO:0009898; C:internal side of plasma membrane; IDA:BHF-UCL. GO:0005758; C:mitochondrial intermembrane space; ISO:MGI. GO:0008635; P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; IDA:MGI. GO:0006917; P:induction of apoptosis; IEA:InterPro. GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; IDA:MGI. GO:0051402; P:neuron apoptotic process; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |