| Tag | Content |
|---|
| CPLM ID | CPLM-001159 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Advillin |
Protein Synonyms/Alias | p92 |
Gene Name | AVIL |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 743 | MRITADMKNATLSLN | ubiquitination | [1] |
|
Reference | [1] Global identification of modular cullin-RING ligase substrates. Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ. Cell. 2011 Oct 14;147(2):459-74. [ PMID: 21963094] |
Functional Description | Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. |
Sequence Annotation | REPEAT 24 73 Gelsolin-like 1.
REPEAT 145 185 Gelsolin-like 2.
REPEAT 262 306 Gelsolin-like 3.
REPEAT 403 454 Gelsolin-like 4.
REPEAT 525 565 Gelsolin-like 5.
REPEAT 628 669 Gelsolin-like 6.
DOMAIN 753 819 HP.
REGION 1 731 Core (By similarity).
REGION 109 116 Polyphosphoinositide binding (By
REGION 135 143 Polyphosphoinositide binding (By
REGION 731 819 Headpiece (By similarity).
MOD_RES 85 85 Phosphotyrosine (By similarity).
MOD_RES 758 758 Phosphotyrosine (By similarity). |
Keyword | 3D-structure; Actin capping; Actin-binding; Alternative splicing; Calcium; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Polymorphism; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 819 AA |
Protein Sequence | MPLTSAFRAV DNDPGIIVWR IEKMELALVP VSAHGNFYEG DCYVILSTRR VASLLSQDIH 60
FWIGKDSSQD EQSCAAIYTT QLDDYLGGSP VQHREVQYHE SDTFRGYFKQ GIIYKQGGVA 120
SGMKHVETNT YDVKRLLHVK GKRNIRATEV EMSWDSFNRG DVFLLDLGKV IIQWNGPESN 180
SGERLKAMLL AKDIRDRERG GRAKIGVIEG DKEAASPELM KVLQDTLGRR SIIKPTVPDE 240
IIDQKQKSTI MLYHISDSAG QLAVTEVATR PLVQDLLNHD DCYILDQSGT KIYVWKGKGA 300
TKAEKQAAMS KALGFIKMKS YPSSTNVETV NDGAESAMFK QLFQKWSVKD QTMGLGKTFS 360
IGKIAKVFQD KFDVTLLHTK PEVAAQERMV DDGNGKVEVW RIENLELVPV EYQWYGFFYG 420
GDCYLVLYTY EVNGKPHHIL YIWQGRHASQ DELAASAYQA VEVDRQFDGA AVQVRVRMGT 480
EPRHFMAIFK GKLVIFEGGT SRKGNAEPDP PVRLFQIHGN DKSNTKAVEV PAFASSLNSN 540
DVFLLRTQAE HYLWYGKGSS GDERAMAKEL ASLLCDGSEN TVAEGQEPAE FWDLLGGKTP 600
YANDKRLQQE ILDVQSRLFE CSNKTGQFVV TEITDFTQDD LNPTDVMLLD TWDQVFLWIG 660
AEANATEKES ALATAQQYLH THPSGRDPDT PILIIKQGFE PPIFTGWFLA WDPNIWSAGK 720
TYEQLKEELG DAAAIMRITA DMKNATLSLN SNDSEPKYYP IAVLLKNQNQ ELPEDVNPAK 780
KENYLSEQDF VSVFGITRGQ FAALPGWKQL QMKKEKGLF 819 |
Gene Ontology | GO:0015629; C:actin cytoskeleton; TAS:ProtInc. GO:0030424; C:axon; IEA:UniProtKB-SubCell. GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0043005; C:neuron projection; ISS:UniProtKB. GO:0003779; F:actin binding; ISS:UniProtKB. GO:0051693; P:actin filament capping; IEA:UniProtKB-KW. GO:0060271; P:cilium morphogenesis; IMP:UniProtKB. GO:0007010; P:cytoskeleton organization; IEA:InterPro. GO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB. GO:0006950; P:response to stress; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |