| Tag | Content |
|---|
| CPLM ID | CPLM-014096 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rho GTPase-activating protein SYDE2 |
Protein Synonyms/Alias | Synapse defective protein 1 homolog 2; Protein syd-1 homolog 2 |
Gene Name | SYDE2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 260 | NAYGSSMKGRELEEL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity). |
Sequence Annotation | DOMAIN 681 781 C2.
DOMAIN 816 1031 Rho-GAP.
MOD_RES 622 622 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; GTPase activation; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1194 AA |
Protein Sequence | MHDLPPDSGA RRGGRGLADH SFPAGARAPG QPPSRGAAYR RACPRDGERG GGGRPRQQVS 60
PPRSPQREPR GGQLRTPRMR PSCSRSLESL RVGAKPPPFQ RWPSDSWIRC GAHRDWDEPP 120
PRGGRMDGWS GDRARAAAPT GLQPPGCKDH GCSSGSPFRD PAGSSVIRSG KGDRQEGPSF 180
LRPPAVTVKK LQKWMYKGRL LSLGMKGRAR GTAPKVTGTQ AASPNVGALK VRENRVLSVP 240
PDQRITLTDL FENAYGSSMK GRELEELKDN IEFRGHKPLN SITVSKKRNW LYQSTLRPLN 300
LEEENKKCQD RSHLSISPVS LPKHQLSQSF LKSSKEYCTY VVCNATNSSL SKNCALDFNE 360
ENDADDEGEI WYNPIPEDDD LGISSALSFG EADSAVLKLP AVNLSMLSGS DLMKAERHTE 420
DSLCSSEHAG DIQTTRSNGM NPIHPAHSTE FVQQYKQKLG HKTQEGIMVE DSPMLKSPFA 480
GSGILAATNS TELGIMEPSS PNPSPVKKGS SINWSLPDKI KSPRTVRKLS MKMKKLPEFS 540
RKLSVKGTLN YINSPDNTPS LSKYNCREVH HTDILPSGNT TTAAKRNVIS RYHLDTSVSS 600
QQSYQKKNSM SSKYSCKGGY LSDGDSPELT TKASKHGSEN KFGKGKEIIS NSCSKNEIDI 660
DAFRHYSFSD QPKCSQYISG LMSVHFYGAE DLKPPRIDSK DVFCAIQVDS VNKARTALLT 720
CRTTFLDMDH TFNIEIENAQ HLKLVVFSWE PTPRKNRVCC HGTVVLPTLF RVTKTHQLAV 780
KLEPRGLIYV KVTLMEQWEN SLHGLDINQE PIIFGVDIQK VVEKENIGLM VPLLIQKCIM 840
EIEKRGCQVV GLYRLCGSAA VKKELREAFE RDSKAVGLCE NQYPDINVIT GVLKDYLREL 900
PSPLITKQLY EAVLDAMAKS PLKMSSNGCE NDPGDSKYTV DLLDCLPEIE KATLKMLLDH 960
LKLVASYHEV NKMTCQNLAV CFGPVLLSQR QEPSTHNNRV FTDSEELASA LDFKKHIEVL 1020
HYLLQLWPVQ RLTVKKSTDN LFPEQKSSLN YLRQKKERPH MLNLSGTDSS GVLRPRQNRL 1080
DSPLSNRYAG DWSSCGENYF LNTKENLNDV DYDDVPSEDR KIGENYSKMD GPEVMIEQPI 1140
PMSKECTFQT YLTMQTVEST VDRKNNLKDL QESIDTLIGN LERELNKNKL NMSF 1194 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005100; F:Rho GTPase activator activity; ISS:UniProtKB. GO:0032862; P:activation of Rho GTPase activity; ISS:UniProtKB. GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |