UniProt Accession

 ITB6_MOUSE; Q9Z0T9; Q544J9 

Genbank Protein ID

 AF115376; AK036439; BC049185 

Genbank Nucleotide ID

 AAD17212.1; BAC29430.1; AAH49185.1 

Protein Name

 Integrin beta-6 

Protein Synonyms/Alias

  

Gene Name

 Itgb6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
752	EAERSKAKWQTGTNP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands (By similarity). 

Sequence Annotation

 DOMAIN 131 371 VWFA.
 REPEAT 456 501 I.
 REPEAT 502 543 II.
 REPEAT 544 582 III.
 REPEAT 583 619 IV.
 REGION 456 619 Cysteine-rich tandem repeats.
 REGION 730 757 Interaction with HAX1 (By similarity).
 CARBOHYD 48 48 N-linked (GlcNAc...) (Potential).
 CARBOHYD 97 97 N-linked (GlcNAc...) (Potential).
 CARBOHYD 260 260 N-linked (GlcNAc...) (Potential).
 CARBOHYD 387 387 N-linked (GlcNAc...) (Potential).
 CARBOHYD 418 418 N-linked (GlcNAc...) (Potential).
 CARBOHYD 463 463 N-linked (GlcNAc...) (Potential).
 CARBOHYD 471 471 N-linked (GlcNAc...) (Potential).
 CARBOHYD 541 541 N-linked (GlcNAc...) (Potential).
 CARBOHYD 575 575 N-linked (GlcNAc...) (Potential).
 DISULFID 23 454 By similarity.
 DISULFID 31 41 By similarity.
 DISULFID 34 70 By similarity.
 DISULFID 44 59 By similarity.
 DISULFID 197 204 By similarity.
 DISULFID 252 293 By similarity.
 DISULFID 394 406 By similarity.
 DISULFID 426 669 By similarity.
 DISULFID 452 456 By similarity.
 DISULFID 467 479 By similarity.
 DISULFID 476 511 By similarity.
 DISULFID 481 490 By similarity.
 DISULFID 492 502 By similarity.
 DISULFID 517 522 By similarity.
 DISULFID 519 552 By similarity.
 DISULFID 524 537 By similarity.
 DISULFID 539 544 By similarity.
 DISULFID 558 563 By similarity.
 DISULFID 560 591 By similarity.
 DISULFID 565 574 By similarity.
 DISULFID 576 583 By similarity.
 DISULFID 597 602 By similarity.
 DISULFID 599 645 By similarity.
 DISULFID 604 614 By similarity.
 DISULFID 617 620 By similarity.
 DISULFID 624 633 By similarity.
 DISULFID 630 701 By similarity.
 DISULFID 649 677 By similarity.  

Keyword

 Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein; Integrin; Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 787 AA 

Protein Sequence

Gene Ontology

 GO:0008305; C:integrin complex; IEA:InterPro.
 GO:0004872; F:receptor activity; IEA:InterPro.
 GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
 GO:0006954; P:inflammatory response; IMP:MGI.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:InterPro. 

Interpro

 IPR015812; Integrin_bsu.
 IPR015436; Integrin_bsu-6.
 IPR014836; Integrin_bsu_cyt_dom.
 IPR002369; Integrin_bsu_N.
 IPR012896; Integrin_bsu_tail.
 IPR003659; Plexin-like.
 IPR016201; Plexin-like_fold.
 IPR002035; VWF_A. 

Pfam

 PF08725; Integrin_b_cyt
 PF07965; Integrin_B_tail
 PF00362; Integrin_beta 

SMART

 SM00187; INB
 SM00423; PSI
 SM00327; VWA 

PROSITE

 PS00022; EGF_1
 PS01186; EGF_2
 PS00243; INTEGRIN_BETA
 PS50234; VWFA 

PRINTS

 PR01186; INTEGRINB.