UniProt Accession

 HIPB_ECOLI; P23873 

Genbank Protein ID

 M61242; U00096; AP009048 

Genbank Nucleotide ID

 AAA56877.1; AAC74581.1; BAA15180.1 

Protein Name

 Antitoxin HipB 

Protein Synonyms/Alias

  

Gene Name

 hipB 

Gene Synonyms/Alias

 b1508; JW1501 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
18	TQLANAMKLVRQQNG	acetylation	[1]
33	WTQSELAKKIGIKQA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Antitoxin component of a toxin-antitoxin (TA) module. Neutralizes the toxic effect of cognate toxin HipA. Binds to operator sites with the consensus sequence 5-'TATCCN(8)GGATA-3' to repress the hipBA operon promoter. 

Sequence Annotation

 DOMAIN 17 71 HTH cro/C1-type.
 DNA_BIND 28 47 H-T-H motif (Potential).  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 88 AA 

Protein Sequence

Gene Ontology

 GO:0043565; F:sequence-specific DNA binding; IDA:EcoCyc.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IDA:EcoCyc. 

Interpro

 IPR001387; HTH.
 IPR010982; Lambda_DNA-bd_dom. 

Pfam

 PF01381; HTH_3 

SMART

 SM00530; HTH_XRE 

PROSITE

 PS50943; HTH_CROC1 

PRINTS