UniProt Accession

 PEX5_HUMAN; P50542; A8K891; B4DZ45; B7ZAD5; D3DUT8; Q15115; Q15266; Q96FN7 

Genbank Protein ID

 U19721; Z48054; X84899; AK292256; AK302742; AK316250; AC018653; CH471116; CH471116; CH471116; BC010621 

Genbank Nucleotide ID

 AAC50103.1; CAA88131.1; CAA59324.1; BAF84945.1; BAG63957.1; BAH14621.1; EAW88671.1; EAW88674.1; EAW88672.1; AAH10621.1 

Protein Name

 Peroxisomal targeting signal 1 receptor 

Protein Synonyms/Alias

 PTS1 receptor; PTS1R; PTS1-BP; Peroxin-5; Peroxisomal C-terminal targeting signal import receptor; Peroxisome receptor 1 

Gene Name

 PEX5 

Gene Synonyms/Alias

 PXR1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
209	VAKVDDPKLANSEFL	ubiquitination	[1]
217	LANSEFLKFVRQIGE	ubiquitination	[1]
278	DMEFERAKSAIESDV	ubiquitination	[2]
456	GAGLGPSKRILGSLL	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. 

Sequence Annotation

 REPEAT 335 368 TPR 1.
 REPEAT 369 402 TPR 2.
 REPEAT 403 436 TPR 3.
 REPEAT 452 485 TPR 4.
 REPEAT 488 521 TPR 5.
 REPEAT 522 555 TPR 6.
 REPEAT 556 589 TPR 7.
 CROSSLNK 11 11 Glycyl cysteine thioester (Cys-Gly)  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; Membrane; Peroxisome; Peroxisome biogenesis disorder; Protein transport; Reference proteome; Repeat; Thioester bond; TPR repeat; Transport; Ubl conjugation; Zellweger syndrome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 639 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005782; C:peroxisomal matrix; IDA:UniProtKB.
 GO:0005778; C:peroxisomal membrane; IDA:UniProtKB.
 GO:0043234; C:protein complex; IDA:UniProtKB.
 GO:0005052; F:peroxisome matrix targeting signal-1 binding; IDA:UniProtKB.
 GO:0048468; P:cell development; IEA:Compara.
 GO:0021795; P:cerebral cortex cell migration; IEA:Compara.
 GO:0021895; P:cerebral cortex neuron differentiation; IEA:Compara.
 GO:0007029; P:endoplasmic reticulum organization; IEA:Compara.
 GO:0006635; P:fatty acid beta-oxidation; IEA:Compara.
 GO:0007006; P:mitochondrial membrane organization; IEA:Compara.
 GO:1901094; P:negative regulation of protein homotetramerization; IDA:UniProtKB.
 GO:0050905; P:neuromuscular process; IEA:Compara.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0040018; P:positive regulation of multicellular organism growth; IEA:Compara.
 GO:0016558; P:protein import into peroxisome matrix; IGI:UniProtKB.
 GO:0016560; P:protein import into peroxisome matrix, docking; IDA:UniProtKB.
 GO:0016561; P:protein import into peroxisome matrix, translocation; IDA:UniProtKB.
 GO:0045046; P:protein import into peroxisome membrane; IMP:UniProtKB.
 GO:0051262; P:protein tetramerization; IDA:UniProtKB.
 GO:0000038; P:very long-chain fatty acid metabolic process; IEA:Compara. 

Interpro

 IPR024111; PTS1R_family.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 

Pfam

 PF00515; TPR_1 

SMART

 SM00028; TPR 

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS