CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014875
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hemogen 
Protein Synonyms/Alias
 Hemopoietic gene protein; Protein RP59 
Gene Name
 Hemgn 
Gene Synonyms/Alias
 Rp59 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
391HQEAVEPKFLSHKTYacetylation[1]
396EPKFLSHKTYKEFTVacetylation[1]
410VPIVSSHKTIQESPGacetylation[1]
447CKNRDGPKHSLPEGAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) (By similarity). 
Sequence Annotation
 REGION 7 87 Necessary for nuclear localization (By  
Keyword
 Complete proteome; Developmental protein; Differentiation; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 514 AA 
Protein Sequence
MDVRKDQSHL TLNQTPEAHV EKSHAPDIIG SWSLRNREQL KKRKAEAQGR QTSQWQLGEQ 60
KKRKYQRTGK GNRRGRKRQG NVEQKAESWS QTENERVQEV LVPAEEETEY SGNTATQALP 120
LRASPTKAVP TEHCSEVPQE SLQCQEITIQ NHSQTHQRRD KAEALSPTTC QEIGVLQYSP 180
KMCQDMAEPE ARSPKMCQET AVPQTYSPKA HEDMAEYEAL SPKMCRETPV PQYHSSKIPQ 240
DMTGPEALAP DMCQETTVSQ NHSSKVPQDM AGPEALSLKM CQEPTVLQEH TLKICQDVAR 300
PDVLSSKTHQ EMTVPKALPC ITPGDAAGPE GCSPKTLPQS DVTPMSVTPG KNTSHPDLGT 360
AVAEGCFSEA GECIVSEDIS TKTHQEAVEP KFLSHKTYKE FTVPIVSSHK TIQESPGPEE 420
YSPGSRHEMS GPEDLSIKTC KNRDGPKHSL PEGAQEVGGA QRQDPDAQDI EDAGAFSQDL 480
EEGNKADQDP ETPAGPQGPQ KICPENDVHS SALF 514 
Gene Ontology
 GO:0005654; C:nucleoplasm; IEA:Compara.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0045667; P:regulation of osteoblast differentiation; IDA:RGD. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS