CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006531
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA-directed RNA polymerase III subunit RPC8 
Protein Synonyms/Alias
 RNA polymerase III subunit C8; DNA-directed RNA polymerase III 25 kDa polypeptide; RNA polymerase III subunit C25 
Gene Name
 RPC25 
Gene Synonyms/Alias
 YKL144C; UNF1; YKL1 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
6**MFILSKIADLVRIubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNA. The RPC25/RPC8-RPC17/RPC9 subcomplex may bind Pol III transcripts emerging from the adjacent exit pore during elongation. 
Sequence Annotation
 MOD_RES 162 162 Phosphoserine.  
Keyword
 3D-structure; Complete proteome; DNA-directed RNA polymerase; Nucleus; Phosphoprotein; Reference proteome; Transcription. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 212 AA 
Protein Sequence
MFILSKIADL VRIPPDQFHR DTISAITHQL NNKFANKIIP NVGLCITIYD LLTVEEGQLK 60
PGDGSSYINV TFRAVVFKPF LGEIVTGWIS KCTAEGIKVS LLGIFDDIFI PQNMLFEGCY 120
YTPEESAWIW PMDEETKLYF DVNEKIRFRI EREVFVDVKP KSPKERELEE RAQLENEIEG 180
KNEETPQNEK PPAYALLGSC QTDGMGLVSW WE 212 
Gene Ontology
 GO:0005666; C:DNA-directed RNA polymerase III complex; IDA:SGD.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-KW.
 GO:0006384; P:transcription initiation from RNA polymerase III promoter; IMP:SGD.
 GO:0042797; P:tRNA transcription from RNA polymerase III promoter; IDA:SGD. 
Interpro
 IPR012340; NA-bd_OB-fold.
 IPR013238; RNA_pol_III_Rbc25.
 IPR005576; RNA_pol_Rpb7_N.
 IPR004519; RNAP_E/RPC8. 
Pfam
 PF08292; RNA_pol_Rbc25
 PF03876; SHS2_Rpb7-N 
SMART
  
PROSITE
  
PRINTS