CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037104
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rho guanine nucleotide exchange factor 3 
Protein Synonyms/Alias
  
Gene Name
 ARHGEF3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
382FSNNERIKNFFRVSFubiquitination[1]
390NFFRVSFKNGSQSQTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 497 AA 
Protein Sequence
MIEEPSNKRV KPLSRVTSLA NLIPPVKATP LKRFSQTLQR SISFRSESRP DILAPRPWSR 60
NAAPSSTKRR DSKLWSETFD VCVNQMLTSK EIKRQEAIFE LSQGEEDLIE DLKLAKKAYH 120
DPMLKLSIMT EQELNQIFGT LDSLIPLHEE LLSQLRDVRK PDGSTEHVGP ILVGWLPCLS 180
SYDSYCSNQV AAKALLDHKK QDHRVQDFLQ RCLESPFSRK LDLWNFLDIP RSRLVKYPLL 240
LREILRHTPN DNPDQQHLEE AINIIQGIVA EINTKTGESE CRYYKERLLY LEEGQKDSLI 300
DSSRVLCCHG ELKNNRGVKL HVFLFQEVLV ITRAVTHNEQ LCYQLYRQPI PVKDLLLEDL 360
QDGEVRLGGS LRGAFSNNER IKNFFRVSFK NGSQSQTHSL QANDTFNKQQ WLNCIRQAKE 420
TVLCAAGQAG VLDSEGSFLN PTTGSRELQG ETKLEQMDQS DSESDCSMDT SEVSLDCERM 480
EQTDSSCGNS RHGESNV 497 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR001331; GDS_CDC24_CS.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR015721; RhoGEF-like. 
Pfam
 PF00621; RhoGEF 
SMART
 SM00233; PH
 SM00325; RhoGEF 
PROSITE
 PS00741; DH_1
 PS50010; DH_2
 PS50003; PH_DOMAIN 
PRINTS