UniProt Accession

 PAA1_YEAST; Q12447; D6VS57 

Genbank Protein ID

 Z46796; Z74367; AY557672; BK006938 

Genbank Nucleotide ID

 CAA86793.1; CAA98889.1; AAS55998.1; DAA11917.1 

Protein Name

 Polyamine N-acetyltransferase 1 

Protein Synonyms/Alias

 Arylalkylamine N-acetyltransferase homolog; scAANAT 

Gene Name

 PAA1 

Gene Synonyms/Alias

 YDR071C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
168	AENTNVAKDKNFAEQ	acetylation	[1]
168	AENTNVAKDKNFAEQ	ubiquitination	[2]
170	NTNVAKDKNFAEQKW	ubiquitination	[2]
176	DKNFAEQKWIDMERE	acetylation	[1]
186	DMERELIKEEYDN**	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Acetylates spermine and probably also other polyamines such as putrescine or spermidine. May regulate the levels of polyamines on chromosomal DNA, which would modify chromatin structure and affect transcription or replication. Also able to acetylate arylalkylamines such as tryptamine and serotonin in vitro. 

Sequence Annotation

 DOMAIN 12 179 N-acetyltransferase.  

Keyword

 Acyltransferase; Complete proteome; Cytoplasm; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 191 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0004059; F:aralkylamine N-acetyltransferase activity; IDA:SGD.
 GO:0004145; F:diamine N-acetyltransferase activity; IMP:SGD.
 GO:0006325; P:chromatin organization; IMP:SGD. 

Interpro

 IPR016181; Acyl_CoA_acyltransferase.
 IPR000182; GNAT_dom. 

Pfam

 PF00583; Acetyltransf_1 

SMART

  

PROSITE

 PS51186; GNAT 

PRINTS