CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021775
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RNA binding protein fox-1 homolog 1 
Protein Synonyms/Alias
 Ataxin-2-binding protein 1; Fox-1 homolog A 
Gene Name
 Rbfox1 
Gene Synonyms/Alias
 A2bp; A2bp1; Fox1; MNCb-3035 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
194DADRAREKLHGTVVEubiquitination[1]
204GTVVEGRKIEVNNATubiquitination[1]
219ARVMTNKKTVNPYTNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. 
Sequence Annotation
 DOMAIN 116 192 RRM.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 396 AA 
Protein Sequence
MLASQGVLLH SYGVPMIVPA APYFPGLMQG NQEAAAAPDT MAQPYASAQF APPQNGIPAE 60
YTAPHPHPAP EYTGQTTVPD HTLNLYPPTQ THSEQSADTS AQTVSGTATQ TDDAAPTDGQ 120
PQTQPSENTE SKSQPKRLHV SNIPFRFRDP DLRQMFGQFG KILDVEIIFN ERGSKGFGFV 180
TFENSADADR AREKLHGTVV EGRKIEVNNA TARVMTNKKT VNPYTNGWKL NPVVGAVYSP 240
DFYAGTVLLC QANQEGSSMY SGPSSLVYTS AMPGFPYPAA TAAAAYRGAH LRGRGRTVYN 300
TFRAAAPPPP IPAYGGVVYQ EPVYGNKLLQ GGYAAYRYAQ PTPATAAAYS DSYGRVYAAD 360
PYHHTLAPAP TYGVGAMNAF APLTDAKTRS HADDVGLVLS SLQASIYRGG YNRFAPY 417 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005802; C:trans-Golgi network; IEA:Compara.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0050885; P:neuromuscular process controlling balance; IGI:MGI.
 GO:0043484; P:regulation of RNA splicing; IEA:InterPro.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 
Interpro
 IPR025670; Fox-1_C_dom.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR017325; RNA-bd_Fox-1.
 IPR000504; RRM_dom. 
Pfam
 PF12414; Fox-1_C
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS