UniProt Accession

 VEGFD_MOUSE; P97946; A2AIH3 

Genbank Protein ID

 X99572; D89628; AL732475; BC080770 

Genbank Nucleotide ID

 CAA67892.1; BAA14002.1; CAM17370.1; AAH80770.1 

Protein Name

 Vascular endothelial growth factor D 

Protein Synonyms/Alias

 VEGF-D; c-Fos-induced growth factor; FIGF 

Gene Name

 Figf 

Gene Synonyms/Alias

 Vegfd 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
77	WRCRLKLKSLASMDS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-3 (Flt4) receptor. 

Sequence Annotation

 REPEAT 227 242 1; approximate.
 REPEAT 263 278 2.
 REPEAT 282 298 3.
 REPEAT 306 323 4.
 REGION 227 323 4 X 16 AA repeats of C-X(10)-C-X-C-
 CARBOHYD 160 160 N-linked (GlcNAc...) (Potential).
 CARBOHYD 190 190 N-linked (GlcNAc...) (Potential).
 CARBOHYD 292 292 N-linked (GlcNAc...) (Potential).
 DISULFID 116 158 By similarity.
 DISULFID 141 141 Interchain (By similarity).
 DISULFID 147 194 By similarity.
 DISULFID 150 150 Interchain (By similarity).
 DISULFID 151 196 By similarity.  

Keyword

 Angiogenesis; Cleavage on pair of basic residues; Complete proteome; Developmental protein; Differentiation; Disulfide bond; Glycoprotein; Growth factor; Mitogen; Reference proteome; Repeat; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 358 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IDA:MGI.
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0042056; F:chemoattractant activity; IEA:Compara.
 GO:0008083; F:growth factor activity; IDA:MGI.
 GO:0043185; F:vascular endothelial growth factor receptor 3 binding; IDA:MGI.
 GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0008283; P:cell proliferation; IDA:MGI.
 GO:0050930; P:induction of positive chemotaxis; IEA:Compara.
 GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
 GO:0008284; P:positive regulation of cell proliferation; IDA:MGI.
 GO:0060754; P:positive regulation of mast cell chemotaxis; IEA:Compara.
 GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IGI:MGI. 

Interpro

 IPR000072; PD_growth_factor.
 IPR023581; PD_growth_factor_CS. 

Pfam

 PF00341; PDGF 

SMART

 SM00141; PDGF 

PROSITE

 PS00249; PDGF_1
 PS50278; PDGF_2 

PRINTS