CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043167
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Treacle protein 
Protein Synonyms/Alias
  
Gene Name
 Tcof1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
132GKTKTANKTVNSVSHacetylation[1, 2, 3]
144VSHPGSGKTVVHLLSacetylation[2, 3]
153VVHLLSGKSPKKSAEacetylation[3]
241RTAPGPTKLGNVAPTacetylation[4]
318SAKGISGKGPILATPacetylation[3]
327PILATPGKTGPAATQacetylation[3]
459VTPGSSGKGANLPCPacetylation[3]
509KAKPALEKQMKASSRacetylation[3]
578STPRVQGKSGGKGLQacetylation[3]
582VQGKSGGKGLQGKAAacetylation[3]
874RAASQPSKSEQSSRMacetylation[3]
928GKSKLPEKQQLAPGYacetylation[3, 4]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1056 AA 
Protein Sequence
MAEARKRREL LPLIYHHLLQ AGYVRAAREV KEQSGQKSFL TQPVTLLDIY THWQQTSELG 60
QKQKAEDDET LQAKKSRVSD PVSSSESSDQ EKEEEAATER AKATPRPTPV NSATAALPSK 120
VKEKGKTKTA NKTVNSVSHP GSGKTVVHLL SGKSPKKSAE PLANTVLASE TEEEGNAQAL 180
GPTAKSGTVS AGQGSSSSED SSISSDETDV EVKSPAKPAQ AKASAAPAKD PPARTAPGPT 240
KLGNVAPTPA KPARAAAAAA AAAVAAAAAA AAEESESSEE DSDSEDEAPA GLPSQVKASG 300
KGPHVRADSV SAKGISGKGP ILATPGKTGP AATQAKAERP EKDSETSSED DSDSEDEMPV 360
TVNTPQARTS GKSPRARGTS APAKESSQKG APAVTPGKAR PVAAQAGKPE AKSSEESESD 420
SGETPAAATL TTSPAKVKPL GKSSQVRPVS TVTPGSSGKG ANLPCPGKVG SAALRVQMVK 480
KEDVSESSSA ELDSDGPGSP AKAKPALEKQ MKASSRKGTP ASATGASTSS HCKAGAVTSS 540
ASLSSPALAK GTQRSDVDSS SESESEGAAP STPRVQGKSG GKGLQGKAAL GQGVAPVHTQ 600
KTGPSVKAMA QEDSESLEED SSSEEEDETP AQATPLGRLP QAKANPPPTK TPPASASGKA 660
VAAPTKGKPP VPNSTVSARG QRSVPAAGKA GAPATQAQKG PVAGTGEDSE SSSKEESDSE 720
EETPAQIKPV GKTSQVRAAS APAKESPKKG AHPGTPGKTG SSATQAQPGK TEDSDSSSEE 780
SDSDTEMPSA QAIKSPPVSV NRNSSPAVPA PTPEGVQAVN TTKKASGTTA QSSSSESEDG 840
DEDLIPATQP STYALRTSVT TPAALSRAAS QPSKSEQSSR MPKGKKAKAA ASAQTSSAVE 900
TLPMMPPQSA PIQPKATNKL GKSKLPEKQQ LAPGYPKAPR SSEDSSDTSS EDEEDAKRPQ 960
MPKSAHRLDP DPSQKETVVE ETPTESSEDE MVAPSQSLLS GYMTPGLTVA NSQASKATPR 1020
PDSNSLASSA PATKDNPDGK QKSKSQHAAD TALPKT 1056 
Gene Ontology
 GO:0042790; P:transcription of nuclear large rRNA transcript from RNA polymerase I promoter; IMP:MGI. 
Interpro
 IPR006594; LisH_dimerisation.
 IPR003993; TCS_treacle.
 IPR017859; Treacle-like_TCS. 
Pfam
 PF03546; Treacle 
SMART
 SM00667; LisH 
PROSITE
 PS50896; LISH 
PRINTS
 PR01503; TREACLE.