CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030660
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AP-1 complex subunit mu-1 
Protein Synonyms/Alias
 cDNA FLJ57898, highly similar to Adaptor-relatedprotein complex 1 mu-1 subunit 
Gene Name
 AP1M1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
12AVYVLDLKGKVVQVFubiquitination[1, 2, 3]
69YITQEGHKLETGAPRubiquitination[2, 3]
127SEIVGSIKMRVFLSGubiquitination[2]
145LRLGLNDKVLFDNTGubiquitination[2, 3, 4]
157NTGRGKSKSVELEDVubiquitination[2, 3]
165SVELEDVKFHQCVRLubiquitination[2, 3]
252PNDADSPKFKTTVGSubiquitination[2, 3, 4]
254DADSPKFKTTVGSVKubiquitination[2, 3]
261KTTVGSVKWVPENSEubiquitination[2]
274SEIVWSIKSFPGGKEubiquitination[2, 4]
324GIQVRYLKIIEKSGYacetylation[5]
324GIQVRYLKIIEKSGYubiquitination[2]
328RYLKIIEKSGYQALPubiquitination[2, 3, 4, 6]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 351 AA 
Protein Sequence
MSASAVYVLD LKGKVVQVFS EYFKELEEES IRDNFVIIYE LLDELMDFGY PQTTDSKILQ 60
EYITQEGHKL ETGAPRPPAT VTNAVSWRSE GIKYRKNEVF LDVIESVNLL VSANGNVLRS 120
EIVGSIKMRV FLSGMPELRL GLNDKVLFDN TGRGKSKSVE LEDVKFHQCV RLSRFENDRT 180
ISFIPPDGEF ELMSYRLNTH VKPLIWIESV IEKHSHSRIE YMIKAKSQFK RRSTANNVEI 240
HIPVPNDADS PKFKTTVGSV KWVPENSEIV WSIKSFPGGK EYLMRAHFGL PSVEAEDKEG 300
KPPISVKFEI PYFTTSGIQV RYLKIIEKSG YQALPWVRYI TQNGDYQLRT Q 351 
Gene Ontology
 GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IEA:InterPro. 
Interpro
 IPR001392; Clathrin_mu.
 IPR008968; Clathrin_mu_C.
 IPR018240; Clathrin_mu_CS.
 IPR011012; Longin-like_dom. 
Pfam
 PF00928; Adap_comp_sub 
SMART
  
PROSITE
 PS00990; CLAT_ADAPTOR_M_1
 PS00991; CLAT_ADAPTOR_M_2
 PS51072; MHD 
PRINTS
 PR00314; CLATHRINADPT.