UniProt Accession

 PCY1A_RAT; P19836 

Genbank Protein ID

 M36071; U03490; L13245; BC085713 

Genbank Nucleotide ID

 AAA40995.1; AAB60489.1; AAB59683.1; AAH85713.1 

Protein Name

 Choline-phosphate cytidylyltransferase A 

Protein Synonyms/Alias

 CCT-alpha; CTP:phosphocholine cytidylyltransferase A; CCT A; CT A; Phosphorylcholine transferase A 

Gene Name

 Pcyt1a 

Gene Synonyms/Alias

 Ctpct; Pcyt1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
33	EEDGIPSKVQRCAVG	acetylation	[1]
57	EIEVDFSKPYVRVTM	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Controls phosphatidylcholine synthesis. 

Sequence Annotation

 REPEAT 319 324 1.
 REPEAT 329 333 2; approximate.
 REPEAT 343 348 3.
 NP_BIND 84 92 CTP.
 NP_BIND 168 169 CTP.
 NP_BIND 196 200 CTP.
 REGION 228 287 Amphipathic (Potential).
 REGION 256 288 3 X 11 AA approximate tandem repeats.
 REGION 298 315 Amphipathic (Potential).
 REGION 319 348 3 X repeats.
 BINDING 122 122 CTP.
 BINDING 122 122 Substrate.
 BINDING 151 151 Substrate.
 BINDING 173 173 CTP.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 8 8 N6-acetyllysine (By similarity).
 MOD_RES 315 315 Phosphoserine; by PKC.
 MOD_RES 319 319 Phosphoserine.
 MOD_RES 321 321 Phosphoserine.
 MOD_RES 322 322 Phosphoserine.
 MOD_RES 323 323 Phosphoserine.
 MOD_RES 329 329 Phosphoserine.
 MOD_RES 331 331 Phosphoserine.
 MOD_RES 333 333 Phosphoserine; by PKC.
 MOD_RES 343 343 Phosphoserine.
 MOD_RES 345 345 Phosphoserine.
 MOD_RES 346 346 Phosphoserine.
 MOD_RES 347 347 Phosphoserine.
 MOD_RES 350 350 Phosphoserine.
 MOD_RES 352 352 Phosphoserine.
 MOD_RES 362 362 Phosphoserine; by CK2.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Lipid biosynthesis; Lipid metabolism; Membrane; Nucleotidyltransferase; Phospholipid biosynthesis; Phospholipid metabolism; Phosphoprotein; Reference proteome; Repeat; Transferase; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 367 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:Compara.
 GO:0019898; C:extrinsic to membrane; NAS:RGD.
 GO:0042587; C:glycogen granule; IEA:Compara.
 GO:0004105; F:choline-phosphate cytidylyltransferase activity; IDA:UniProtKB.
 GO:0008289; F:lipid binding; IMP:RGD.
 GO:0009628; P:response to abiotic stimulus; IEA:Compara. 

Interpro

 IPR004821; Cyt_trans-like.
 IPR014729; Rossmann-like_a/b/a_fold. 

Pfam

 PF01467; CTP_transf_2 

SMART

  

PROSITE

  

PRINTS