UniProt Accession

 KAT8_HUMAN; Q9H7Z6; A8K4Z1; G5E9P2; Q659G0; Q7LC17; Q8IY59; Q8WYB4; Q8WZ14; Q9HAC5; Q9NR35 

Genbank Protein ID

 AK021872; AK024102; AK291106; AC009088; AC135050; CH471192; CH471192; BC037773; AF217501; AF260665; AF289578; AL050395 

Genbank Nucleotide ID

 BAB13924.1; BAB14827.1; BAF83795.1; EAW52157.1; EAW52158.1; AAH37773.1; AAL56648.1; AAF72665.2; AAL55762.1; CAH56416.1 

Protein Name

 Histone acetyltransferase KAT8 

Protein Synonyms/Alias

 Lysine acetyltransferase 8; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST-1; hMOF 

Gene Name

 KAT8 

Gene Synonyms/Alias

 MOF; MYST1; PP7073 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
106	RLDEWVDKNRLALTK	ubiquitination	[1]
113	KNRLALTKTVKDAVQ	ubiquitination	[1]
125	AVQKNSEKYLSELAE	ubiquitination	[1]
427	KLVEEHLKSAQYKKP	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. 

Sequence Annotation

 DOMAIN 69 123 Chromo.
 ZN_FING 208 230 C2HC-type.
 REGION 174 458 Sufficient for interaction with KANSL1.
 REGION 324 330 Acetyl-CoA binding.
 ACT_SITE 274 274
 ACT_SITE 316 316 Nucleophile (By similarity).
 BINDING 319 319 Acetyl-CoA.
 BINDING 354 354 Acetyl-CoA.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 37 37 Phosphoserine (By similarity).
 MOD_RES 42 42 Phosphoserine (By similarity).
 MOD_RES 113 113 N6-acetyllysine.
 MOD_RES 274 274 N6-acetyllysine; by autocatalysis.  

Keyword

 3D-structure; Acetylation; Activator; Acyltransferase; Alternative splicing; Chromatin regulator; Chromosome; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Transferase; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 458 AA 

Protein Sequence

Gene Ontology

 GO:0000776; C:kinetochore; IEA:Compara.
 GO:0071339; C:MLL1 complex; IDA:UniProtKB.
 GO:0072487; C:MSL complex; IDA:UniProtKB.
 GO:0004402; F:histone acetyltransferase activity; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0035064; F:methylated histone residue binding; IDA:UniProtKB.
 GO:0008134; F:transcription factor binding; IDA:UniProtKB.
 GO:0043984; P:histone H4-K16 acetylation; IDA:UniProtKB.
 GO:0043981; P:histone H4-K5 acetylation; IDA:UniProtKB.
 GO:0043982; P:histone H4-K8 acetylation; IDA:UniProtKB.
 GO:0030099; P:myeloid cell differentiation; IDA:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR016181; Acyl_CoA_acyltransferase.
 IPR000953; Chromo_domain/shadow.
 IPR016197; Chromodomain-like.
 IPR002717; MOZ_SAS.
 IPR025995; Tudor-knot. 

Pfam

 PF01853; MOZ_SAS
 PF11717; Tudor-knot 

SMART

 SM00298; CHROMO 

PROSITE

 PS00598; CHROMO_1
 PS50013; CHROMO_2 

PRINTS