UniProt Accession

 NAIF1_HUMAN; Q69YI7; B3KV81; Q8WU12 

Genbank Protein ID

 AK122729; AL833392; AL360268; CH471090; BC021580 

Genbank Nucleotide ID

 BAG53693.1; CAH10588.1; CAH73132.1; EAW87735.1; AAH21580.1 

Protein Name

 Nuclear apoptosis-inducing factor 1 

Protein Synonyms/Alias

  

Gene Name

 NAIF1 

Gene Synonyms/Alias

 C9orf90 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
228	RIALNSAKLIQEQRV	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Induces apoptosis. 

Sequence Annotation

 REGION 1 70 Required for nuclear localization and  

Keyword

 Alternative splicing; Apoptosis; Complete proteome; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 327 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0006917; P:induction of apoptosis; IEA:InterPro.
 GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
 GO:1902108; P:regulation of mitochondrial membrane permeability involved in apoptotic process; IDA:UniProtKB. 

Interpro

 IPR026753; NAIF1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS