CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039767
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Anaphase-promoting complex subunit 5 
Protein Synonyms/Alias
  
Gene Name
 ANAPC5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
80ITLSKLYKLIEESCPubiquitination[1]
366VLLEHSVKKAVHFGLubiquitination[2]
367LLEHSVKKAVHFGLPubiquitination[1]
380LPRAFAGKTANKLMDubiquitination[2]
384FAGKTANKLMDALKDubiquitination[1, 2]
390NKLMDALKDSDLLHWubiquitination[1, 2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 742 AA 
Protein Sequence
MASVHESLYF NPMMTNGVVH ANVFGIKDWV TPYKIAVLVL LNEMSRTGEG AVSLMERRRL 60
NQLLLPLLQG PDITLSKLYK LIEESCPQLA NSVQIRIKLM AEGELKDMEQ FFDDLSDSFS 120
GTEPEVHKTS VVGLFLRHMI LAYSKLSFSQ VFKLYTALQQ YFQNGEKKTV EDADMELTSR 180
DEGERKMEKE ELDVSVREEE VSCSGPLSQK QAEFFLSQQA SLLKNDETKA LTPASLQKEL 240
NNLLKFNPDF AEAHYLSYLN NLRVQDVFSS THSLLHYFDR LILTGAESKS NGEEGYGRSL 300
RYAALNLAAL HCRFGHYQQA ELALQEAIRI AQESNDHVCL QHCLSWLYVL GQKRSDSYVL 360
LEHSVKKAVH FGLPRAFAGK TANKLMDALK DSDLLHWKHS LSELIDISIA QKTAIWRLYG 420
RSTMALQQAQ MLLSMNSLEA VNAGVQQNNT ESFAVALCHL AELHAEQGCF AAASEVLKHL 480
KERFPPNSQH AQLWMLCDQK IQFDRAMNDG KYHLADSLVT GITALNSIEG VYRKAVVLQA 540
QNQMSEAHKL LQKLLVHCQK LKNTEMVISV LLSVAELYWR SSSPTIALPM LLQALALSKE 600
YRLQYLASET VLNLAFAQLI LGIPEQALSL LHMAIEPILA DGAILDKGRA MFLVAKCQVA 660
SAASYDQPKK AEALEAAIEN LNEAKNYFAK VDCKERIRDV VYFQARLYHT LGKTQERNRC 720
AMLFRQLHQE LPSHGVPLIN HL 742 
Gene Ontology
  
Interpro
 IPR026000; Apc5_TPR.
 IPR011990; TPR-like_helical. 
Pfam
 PF12862; Apc5 
SMART
  
PROSITE
  
PRINTS