UniProt Accession

 CK5P3_HUMAN; Q96JB5; D3DTU1; D3DTU2; Q53FA2; Q9H3F8; Q9H8G0; Q9HBR9 

Genbank Protein ID

 AF110322; AF217982; AF343090; AB062433; AK023722; AK223387; CH471109; CH471109; CH471109; CH471109; BC009957; BC072435 

Genbank Nucleotide ID

 AAG39277.1; AAG17225.1; AAK69655.1; BAB93496.1; BAB14657.1; BAD97107.1; EAW94772.1; EAW94774.1; EAW94775.1; EAW94778.1; AAH09957.1; AAH72435.1 

Protein Name

 CDK5 regulatory subunit-associated protein 3 

Protein Synonyms/Alias

 CDK5 activator-binding protein C53; Protein HSF-27 

Gene Name

 CDK5RAP3 

Gene Synonyms/Alias

 IC53; MSTP016; OK/SW-cl.114; PP1553 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
166	EQFYHSCKQYGITGE	ubiquitination	[1, 2, 3, 4]
395	AILQGQTKEKMVTMV	ubiquitination	[3]
478	KLDLLLEKTKELQKL	ubiquitination	[3]

Reference

 [1] Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
 Xu G, Paige JS, Jaffrey SR.
 Nat Biotechnol. 2010 Aug;28(8):868-73. [PMID: 20639865]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity). 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 506 AA 

Protein Sequence

Gene Ontology

 GO:0019901; F:protein kinase binding; NAS:UniProtKB.
 GO:0007420; P:brain development; NAS:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; ISS:UniProtKB.
 GO:0045664; P:regulation of neuron differentiation; NAS:UniProtKB. 

Interpro

 IPR008491; DUF773. 

Pfam

 PF05600; DUF773 

SMART

  

PROSITE

  

PRINTS