CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016726
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 mRNA export factor 
Protein Synonyms/Alias
 Rae1 protein homolog; mRNA-associated protein mrnp 41 
Gene Name
 Rae1 
Gene Synonyms/Alias
 Mrnp41 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
252INPPNPAKDNFTFKCubiquitination[1]
363RNAAEELKPRNKK**acetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton (By similarity). 
Sequence Annotation
 REPEAT 37 79 WD 1.
 REPEAT 84 114 WD 2.
 REPEAT 125 157 WD 3.
 REPEAT 168 206 WD 4.
 REPEAT 215 255 WD 5.
 REPEAT 271 301 WD 6.
 REPEAT 310 346 WD 7.
 MOD_RES 229 229 Phosphothreonine (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 368 AA 
Protein Sequence
MSLFGSTSGF GTGGTSMFGS TTTDNHNPMK DIEVTSSPDD SIGCLSFSPP TLPGNFLIAG 60
SWANDVRCWE VQDSGQTIPK AQQMHTGPVL DVCWSDDGSK VFTASCDKTA KMWDLNSNQA 120
IQIAQHDAPV KTIHWIKAPN YSCVMTGSWD KTLKFWDTRS SNPMMVLQLP ERCYCADVIY 180
PMAVVATAER GLIVYQLENQ PSEFRRIESP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV 240
AIHYINPPNP AKDNFTFKCH RSNGTNTSAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW 300
DKDARTKLKT SEQLDQPIAA CCFNHNGNIF AYASSYDWSK GHEFYNPQKK NYIFLRNAAE 360
ELKPRNKK 368 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0071407; P:cellular response to organic cyclic compound; IDA:MGI. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.