CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018141
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 17-beta-hydroxysteroid dehydrogenase 13 
Protein Synonyms/Alias
 17-beta-HSD 13; Alcohol dehydrogenase PAN1B-like; Short-chain dehydrogenase/reductase 9 
Gene Name
 Hsd17b13 
Gene Synonyms/Alias
 Scdr9 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
32FFIPRRRKSVTGQTVubiquitination[1]
58LTAYEFAKQKSRLVLubiquitination[1]
70LVLWDINKRGVEETAacetylation[2]
70LVLWDINKRGVEETAubiquitination[1]
79GVEETADKCRKLGAVacetylation[2, 3, 4, 5]
79GVEETADKCRKLGAVubiquitination[1]
108YNSVDQVKREVGDVEubiquitination[1]
227FVNTGFTKNPSTRLWubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
  
Sequence Annotation
 NP_BIND 40 67 NAD (By similarity).
 ACT_SITE 185 185 Proton acceptor (By similarity).
 BINDING 172 172 Substrate (By similarity).
 BINDING 189 189 NAD (By similarity).
 MOD_RES 35 35 Phosphothreonine.
 MOD_RES 38 38 Phosphothreonine.  
Keyword
 Alternative splicing; Complete proteome; NAD; Oxidoreductase; Phosphoprotein; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 304 AA 
Protein Sequence
MNLILEFLLL VGVIIYSYLE SLVKFFIPRR RKSVTGQTVL ITGAGHGIGR LTAYEFAKQK 60
SRLVLWDINK RGVEETADKC RKLGAVVHVF VVDCSNRAEI YNSVDQVKRE VGDVEIVVNN 120
AGAIYPADLL SAKDEEITKT FEVNILGHFW IIKALLPSML RRNSGHIVTV ASVCGHGVIP 180
YLIPYCSSKF AAVGFHRALT AELDTLGKTG IQTSCLCPVF VNTGFTKNPS TRLWPVLEPE 240
EVARSLINGI LTNKKMIFVP SYINISLILE KGPGFSSKHP HGGSQQPVTP IPGDLTPSSD 300
FLKH 304 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. 
Interpro
 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00106; adh_short 
SMART
  
PROSITE
 PS00061; ADH_SHORT 
PRINTS
 PR00081; GDHRDH.
 PR00080; SDRFAMILY.