CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004541
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Oxygen-insensitive NADPH nitroreductase 
Protein Synonyms/Alias
 Modulator of drug activity A 
Gene Name
 nfsA 
Gene Synonyms/Alias
 mda18; mdaA; ybjB; b0851; JW0835 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
54SIIRITDKALREELVacetylation[1]
141NNIEAVTKLLKLPQHacetylation[1]
167PADNPDLKPRLPASIacetylation[1]
222HIRRTIIKESRPFILacetylation[1]
234FILDYLHKQGWATR*acetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Reduction of nitroaromatic compounds using NADH. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. Major component of the oxygen- insensitive nitroreductase activity in E.coli. 
Sequence Annotation
  
Keyword
 3D-structure; Complete proteome; Flavoprotein; FMN; NAD; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 240 AA 
Protein Sequence
MTPTIELICG HRSIRHFTDE PISEAQREAI INSARATSSS SFLQCSSIIR ITDKALREEL 60
VTLTGGQKHV AQAAEFWVFC ADFNRHLQIC PDAQLGLAEQ LLLGVVDTAM MAQNALIAAE 120
SLGLGGVYIG GLRNNIEAVT KLLKLPQHVL PLFGLCLGWP ADNPDLKPRL PASILVHENS 180
YQPLDKGALA QYDEQLAEYY LTRGSNNRRD TWSDHIRRTI IKESRPFILD YLHKQGWATR 240 
Gene Ontology
 GO:0034567; F:chromate reductase activity; IDA:EcoCyc.
 GO:0010181; F:FMN binding; IDA:EcoCyc.
 GO:0016657; F:oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor; IDA:EcoCyc. 
Interpro
 IPR016446; Nitro/flavin_Rdtase.
 IPR000415; Nitroreductase-like. 
Pfam
 PF00881; Nitroreductase 
SMART
  
PROSITE
  
PRINTS