UniProt Accession

 ELOV5_HUMAN; Q9NYP7; B4DZJ2; F6SH78; Q59EL3; Q5TGH5; Q6NXE7; Q7L2S5; Q8NCG4; Q9UI22 

Genbank Protein ID

 AF231981; AF338241; AL136939; AK074889; AK302948; AB209798; AL034374; AL034374; CH471081; BC017270; BC067123; BC074503; AK074748; AF111849 

Genbank Nucleotide ID

 AAF70631.1; AAM00193.1; CAB66873.1; BAC11270.1; BAG64104.1; BAD93035.1; CAI21530.1; CAI21531.1; EAX04419.1; AAH17270.2; AAH67123.2; BAC11178.1; AAF16688.1 

Protein Name

 Elongation of very long chain fatty acids protein 5 

Protein Synonyms/Alias

 3-keto acyl-CoA synthase ELOVL5; ELOVL fatty acid elongase 5; ELOVL FA elongase 5; Fatty acid elongase 1; hELO1; Very-long-chain 3-oxoacyl-CoA synthase 5 

Gene Name

 ELOVL5 

Gene Synonyms/Alias

 ELOVL2; PRO0530 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
108	TAGESDMKIIRVLWW	ubiquitination	[1]
199	MRPYLWWKKYITQGQ	ubiquitination	[2]
267	SRRKDHLKDHQNGSM	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Condensing enzyme that catalyzes the synthesis of monounsaturated and of polyunsaturated very long chain fatty acids Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. 

Sequence Annotation

 MOD_RES 273 273 Phosphoserine (By similarity).
 MOD_RES 281 281 Phosphothreonine (By similarity).
 MOD_RES 283 283 Phosphoserine (By similarity).
 MOD_RES 285 285 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Membrane; Phosphoprotein; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 299 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0009922; F:fatty acid elongase activity; IDA:UniProtKB.
 GO:0036109; P:alpha-linolenic acid metabolic process; TAS:Reactome.
 GO:0034625; P:fatty acid elongation, monounsaturated fatty acid; IDA:UniProtKB.
 GO:0034626; P:fatty acid elongation, polyunsaturated fatty acid; IDA:UniProtKB.
 GO:0043651; P:linoleic acid metabolic process; TAS:Reactome.
 GO:0035338; P:long-chain fatty-acyl-CoA biosynthetic process; TAS:Reactome.
 GO:0019432; P:triglyceride biosynthetic process; TAS:Reactome.
 GO:0042761; P:very long-chain fatty acid biosynthetic process; IDA:UniProtKB. 

Interpro

 IPR002076; GNS1_SUR4. 

Pfam

 PF01151; ELO 

SMART

  

PROSITE

 PS01188; ELO 

PRINTS