CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044332
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Centrosomal protein of 290 kDa 
Protein Synonyms/Alias
  
Gene Name
 CEP290 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
737NYSQQLAKANLKIDHubiquitination[1]
832YKEYLSEKETWKTESubiquitination[1]
1020NKELEITKEKLHTIEubiquitination[2]
1035QAWEQETKLGNESSMubiquitination[1, 2]
1044GNESSMDKAKKSITNubiquitination[1]
1047SSMDKAKKSITNSDIubiquitination[1]
1338EELISTLKDTKGAQKubiquitination[3]
1519PATAEREKLIAELGRubiquitination[3]
1918LIRWEEGKKWQAKIEmethylation[4]
1923EGKKWQAKIEGIRNKmethylation[4]
2324EDLEQQIKILKHVPEubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2481 AA 
Protein Sequence
MPPNINWKEI MKVDPDDLPR QEELADNLLI SLSKVEVNEL KSEKQENVIH LFRITQSLMK 60
MKAQEVELAL EEVEKAGEEQ AKFENQLKTK VMKLENELEM AQQSAGGRDT RFLRNEICQL 120
EKQLEQKDRE LEDMEKELEK EKKVNEQLAL RNEEAENENS KLRRENKRLK KKNEQLCQDI 180
IDYQKQIDSQ KETLLSRRGE DSDYRSQLSK KNYELIQYLD EIQTLTEANE KIEVQNQEMR 240
KNLEESVQEM EKMTDEYNRM KAIVHQTDNV IDQLKKENDH YQLQVQELTD LLKSKNEEDD 300
PIMVAVNAKV EEWKLILSSK DDEIIEYQQM LHNLREKLKN AQLDADKSNV MALQQGIQER 360
DSQIKMLTEQ VEQYTKEMEK NTCIIEDLKN ELQRNKGAST LSQQTHMKIQ STLDILKEKT 420
KEAERTAELA EADAREKDKE LVEALKRLKD YESGVYGLED AVVEIKNCKN QIKIRDREIE 480
ILTKEINKLE LKISDFLDEN EALRERVGLE PKTMIDLTEF RNSKHLKQQQ YRAENQILLK 540
EASIESLEEE RLDLKKKIRQ MAQERGKRSA TSGLTTEDLN LTENISQGDR ISERKLDLLS 600
LKNMSEAQSK NEFLSRELIE KERDLERSRT VIAKFQNKLK ELVEENKQLE EGMKEILQAI 660
KEMQKDPDVK GGETSLIIPS LERLVNAIES KNAEGIFDAS LHLKAQVDQL TGRNEELRQE 720
LRESRKEAIN YSQQLAKANL KIDHLEKETS LLRQSEGSNV VFKGIDLPDG IAPSSASIIN 780
SQNEYLIHLL QELENKEKKL KNLEDSLEDY NRKFAVIRHQ QSLLYKEYLS EKETWKTESK 840
TIKEEKRKLE DQVQQDAIKV KEYNNLLNAL QMDSDEMKKI LAENSRKITV LQVNEKSLIR 900
QYTTLVELER QLRKENEKQK NELLSMEAEV CEKIGCLQRF KEMAIFKIAA LQKVVDNSVS 960
LSELELANKQ YNELTAKYRD ILQKDNMLVQ RTSNLEHLEC ENISLKEQVE SINKELEITK 1020
EKLHTIEQAW EQETKLGNES SMDKAKKSIT NSDIVSISKK ITMLEMKELN ERQRAEHCQK 1080
MYEHLRTSLK QMEERNFELE TKFAELTKIN LDAQKVEQML RDELADSVSK AVSDADRQRI 1140
LELEKNEMEL KVEVSKLREI SDIARRQVEI LNAQQQSRDK EVESLRMQLL DYQAQSDEKS 1200
LIAKLHQHNV SLQLSEATAL GKLESITSKL QKMEAYNLRL EQKLDEKEQA LYYARLEGRN 1260
RAKHLRQTIQ SLRRQFSGAL PLAQQEKFSK TMIQLQNDKL KIMQEMKNSQ QEHRNMENKT 1320
LEMELKLKGL EELISTLKDT KGAQKVINWH MKIEELRLQE LKLNRELVKD KEEIKYLNNI 1380
ISEYERTISS LEEEIVQQNK FHEERQMAWD QREVDLERQL DIFDRQQNEI LNAAQKFEEA 1440
TGSIPDPSLP LPNQLEIALR KIKENIRIIL ETRATCKSLE EKLKEKESAL RLAEQNILSR 1500
DKVINELRLR LPATAEREKL IAELGRKEME PKSHHTLKIA HQTIANMQAR LNQKEEVLKK 1560
YQRLLEKARE EQREIVKKHE EDLHILHHRL ELQADSSLNK FKQTAWDLMK QSPTPVPTNK 1620
HFIRLAEMEQ TVAEQDDSLS SLLVKLKKVS QDLERQREIT ELKVKEFENI KLQLQENHED 1680
EVKKVKAEVE DLKYLLDQSQ KESQCLKSEL QAQKEANSRA PTTTMRNLVE RLKSQLALKE 1740
KQQKALSRAL LELRAEMTAA AEERIISATS QKEAHLNVQQ IVDRHTRELK TQVEDLNENL 1800
LKLKEALKTS KNRENSLTDN LNDLNNELQK KQKAYNKILR EKEEIDQEND ELKRQIKRLT 1860
SGLQGKPLTD NKQSLIEELQ RKVKKLENQL EGKVEEVDLK PMKEKNAKEE LIRWEEGKKW 1920
QAKIEGIRNK LKEKEGEVFT LTKQLNTLKD LFAKADKEKL TLQRKLKTTG MTVDQVLGIR 1980
ALESEKELEE LKKRNLDLEN DILYMRAHQA LPRDSVVEDL HLQNRYLQEK LHALEKQFSK 2040
DTYSKPSISG IESDDHCQRE QELQKENLKL SSENIELKFQ LEQANKDLPR LKNQVRDLKE 2100
MCEFLKKEKA EVQRKLGHVR GSGRSGKTIP ELEKTIGLMK KVVEKVQREN EQLKKASGIL 2160
TSEKMANIEQ ENEKLKAELE KLKAHLGHQL SMHYESKTKG TEKIIAENER LRKELKKETD 2220
AAEKLRIAKN NLEILNEKMT VQLEETGKRL QFAESRGPQL EGADSKSWKS IVVTRMYETK 2280
LKELETDIAK KNQSITDLKQ LVKEATEREQ KVNKYNEDLE QQIKILKHVP EGAETEQGLK 2340
RELQVLRLAN HQLDKEKAEL IHQIEANKDQ SGAESTIPDA DQLKEKIKDL ETQLKMSDLE 2400
KQHLKEEIKK LKKELENFDP SFFEEIEDLK YNYKEEVKKN ILLEEKVKKL SEQLGVELTS 2460
PVAASEEFED EEESPVNFPI Y 2481 
Gene Ontology
 GO:0005813; C:centrosome; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0060271; P:cilium morphogenesis; IEA:InterPro. 
Interpro
 IPR026201; Cep290. 
Pfam
  
SMART
  
PROSITE
  
PRINTS