CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013021
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Xylulose kinase 
Protein Synonyms/Alias
 Xylulokinase 
Gene Name
 Xylb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
71QGGVHVHKDRLTVTSubiquitination[1]
193FTGNQIAKLFQKNPEubiquitination[1]
197QIAKLFQKNPEAYSHubiquitination[1]
360NGSLMREKIRDESASubiquitination[1]
372SASCSWNKFSKALKSacetylation[2]
372SASCSWNKFSKALKSubiquitination[1]
434IEGQFMAKRIHAEGLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 Phosphorylates D-xylulose to produce D-xylulose 5- phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis (By similarity). 
Sequence Annotation
 NP_BIND 456 457 ATP (By similarity).
 BINDING 114 114 Substrate (By similarity).
 BINDING 185 185 Substrate (By similarity).
 BINDING 295 295 Substrate (By similarity).
 BINDING 296 296 Substrate (By similarity).
 BINDING 370 370 ATP (By similarity).
 BINDING 460 460 ATP (By similarity).  
Keyword
 ATP-binding; Carbohydrate metabolism; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Xylose metabolism. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 551 AA 
Protein Sequence
MDARTHRRAA GTPRALAERA GRRCCLGWDF STQQVKVVAV DAELNVFYED SVHFDRDLPE 60
FGTQGGVHVH KDRLTVTSPV LMWVQALDLI LGKMKSSGFD FSQVLALSGA GQQHGSVYWK 120
TGASLALSSL SPALPLHQQL QSCFSISDCP IWMDSSTTAQ CHQLEAAVGG AQALSCLTGS 180
RAYERFTGNQ IAKLFQKNPE AYSHSERISL VSSFAASLFL GGYSPIDYSD GSGMNLLQIQ 240
EKVWSQACLD VCAPHLEEKL GSPVPSCSVV GTISSYYVQR YGFPPGCKVV AFSGDNPASL 300
AGMRLEEGDI AVSLGTSDTL FLWLQKPMPA LEGHIFCNPV DPQHYMALLC FKNGSLMREK 360
IRDESASCSW NKFSKALKST AMGNNGNLGF YFDVMEITPE IIGRHRFNAE NMEVSAFPGD 420
VEIRALIEGQ FMAKRIHAEG LGYRVMPKTK ILATGGASHN KDILQVLADV FGAPVYVIDT 480
TSSACVGSAY RAFHGLAGGT GVAFSEVVKS APQPSLAATP NPGASQVYAA LLPRYSALEQ 540
RILSTAQRPL E 551 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004856; F:xylulokinase activity; ISS:UniProtKB.
 GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
 GO:0005997; P:xylulose metabolic process; ISS:UniProtKB. 
Interpro
 IPR018485; Carb_kinase_FGGY_C.
 IPR018484; Carb_kinase_FGGY_N. 
Pfam
 PF02782; FGGY_C
 PF00370; FGGY_N 
SMART
  
PROSITE
  
PRINTS