CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016504
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inactive tyrosine-protein kinase 7 
Protein Synonyms/Alias
 Protein chuzhoi; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7 
Gene Name
 Ptk7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
921SNNRFVHKDLAARNCacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. 
Sequence Annotation
 DOMAIN 23 112 Ig-like C2-type 1.
 DOMAIN 120 210 Ig-like C2-type 2.
 DOMAIN 217 309 Ig-like C2-type 3.
 DOMAIN 301 399 Ig-like C2-type 4.
 DOMAIN 404 489 Ig-like C2-type 5.
 DOMAIN 495 578 Ig-like C2-type 6.
 DOMAIN 570 672 Ig-like C2-type 7.
 DOMAIN 788 1058 Protein kinase; inactive.
 REGION 786 1062 Interaction with CTNNB1 (By similarity).
 CARBOHYD 98 98 N-linked (GlcNAc...).
 CARBOHYD 108 108 N-linked (GlcNAc...).
 CARBOHYD 176 176 N-linked (GlcNAc...) (Potential).
 CARBOHYD 206 206 N-linked (GlcNAc...) (Potential).
 CARBOHYD 260 260 N-linked (GlcNAc...) (Potential).
 CARBOHYD 275 275 N-linked (GlcNAc...).
 CARBOHYD 397 397 N-linked (GlcNAc...).
 CARBOHYD 455 455 N-linked (GlcNAc...) (Potential).
 CARBOHYD 559 559 N-linked (GlcNAc...).
 CARBOHYD 638 638 N-linked (GlcNAc...) (Potential).
 DISULFID 45 93 By similarity.
 DISULFID 142 192 By similarity.
 DISULFID 238 293 By similarity.
 DISULFID 335 383 By similarity.
 DISULFID 425 473 By similarity.
 DISULFID 516 562 By similarity.
 DISULFID 605 656 By similarity.  
Keyword
 Cell adhesion; Cell junction; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1062 AA 
Protein Sequence
MGARPLTLLR ALLLPLLAGA QAAIVFIKEP SSQDALQGRR ALLRCEVEAP DPVHVYWLLN 60
GVPVQDTERR FAQGSSLSFA AVDRLQDSGA FQCVARDNVT GEEVRSTNAS FNIKWIEAGP 120
VVLKHPASEA EIQPQTQVTL RCHIDGHPRP TYQWFRDGTP LSDDQSTHTV SSRERNLTLR 180
PASPEHSGLY SCCAHNAFGQ ACSSQNFTLS VADESFARVV LAPQDVVVAR NEEAMFHCQF 240
SAQPPPSLQW VFEDETPITN RSRPPHLRRA VVFANGSLLL TQVRPRNAGV YRCIGQGQRG 300
PPIVLEATLH LAEIEDMLPF EPRVFIAGDE ERVTCPAPQG LPTPSVWWEH AGVPLPAHGR 360
VHQKGLELVF VTIAESDTGV YTCHASNLAG QRRQDVNITV ATVPTWLRKP QDSQLEEGKP 420
GYLHCLTQAT PKPTVIWYRN QMLISEDSRF EVSKNGTLRI NSVEVYDGTL YRCVSSTPAG 480
SIEAQARVQV LEKLKFTPPP QPQQCMEFDK EATVPCSATG REKPTVKWVR ADGSSLPEWV 540
TDNAGTLHFA RVTRDDAGNY TCIASNEPQG QIRAHVQLTV AVFITFKVEP ERTTVYQGHT 600
ALLRCEAQGD PKPLIQWKGK DRILDPTKLG PRMHIFQNGS LVIHDVAPED SGSYTCIAGN 660
SCNIRHTEAP LLVVDKPVME DSEGPGSPPP YKMIQTIGLS VGAAVAYIIA VLGLMFYCKK 720
RCKAKRLQKQ PEGEEPEMEC LNGGPLQNGQ PSAEIQEEVA LTSLGSGPPA TNKRHSAGDR 780
MHFPRASLQP ITTLGKSEFG EVFLAKAQGV EEGATETLVL VKSLQSRDEQ QQLDFRREVE 840
MFGKLNHANV VRLLGLCREA EPHYMVLEYV DLGDLKQFLR ISKNKDEKLK SQPLSTKQKV 900
ALCSQVALGM EHLSNNRFVH KDLAARNCLI SAQRQVKVSA LGLSKDVYNS EYYHFRQAWV 960
PLRWMSPEAV LEGDFSTKSD VWAFGVLMWE VFTHGEMPHG GQADDEVLAD LQAGKARLPQ 1020
PEGCPSKLYR LMQRCWAPNP KDRPSFSEIA STLGDSPADS KQ 1062 
Gene Ontology
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
 GO:0031532; P:actin cytoskeleton reorganization; IEA:Compara.
 GO:0003401; P:axis elongation; IMP:MGI.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0016477; P:cell migration; IEA:Compara.
 GO:0071300; P:cellular response to retinoic acid; IEA:Compara.
 GO:0090103; P:cochlea morphogenesis; IMP:MGI.
 GO:0060026; P:convergent extension; IMP:MGI.
 GO:0045198; P:establishment of epithelial cell apical/basal polarity; IMP:MGI.
 GO:0001736; P:establishment of planar polarity; IMP:MGI.
 GO:0060484; P:lung-associated mesenchyme development; IMP:MGI.
 GO:0001843; P:neural tube closure; IMP:MGI.
 GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IGI:MGI.
 GO:0010976; P:positive regulation of neuron projection development; IEA:Compara.
 GO:0042060; P:wound healing; IGI:MGI. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom. 
Pfam
 PF07679; I-set
 PF07714; Pkinase_Tyr 
SMART
 SM00409; IG
 SM00408; IGc2
 SM00219; TyrKc 
PROSITE
 PS50835; IG_LIKE
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00239; RECEPTOR_TYR_KIN_II 
PRINTS
 PR00109; TYRKINASE.