CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005721
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Chorismate synthase 
Protein Synonyms/Alias
 5-enolpyruvylshikimate-3-phosphate phospholyase 
Gene Name
 ARO2 
Gene Synonyms/Alias
 YGL148W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
6**MSTFGKLFRVTTYacetylation[1]
60LSTPRDEKDRVEIQSacetylation[1]
279NDPFYFEKETNRLRTacetylation[1]
321ATISQEQKTATYDGEubiquitination[2]
335EEGILAAKGRHDPAVacetylation[1]
335EEGILAAKGRHDPAVubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
  
Sequence Annotation
  
Keyword
 3D-structure; Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; Lyase; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 376 AA 
Protein Sequence
MSTFGKLFRV TTYGESHCKS VGCIVDGVPP GMSLTEADIQ PQLTRRRPGQ SKLSTPRDEK 60
DRVEIQSGTE FGKTLGTPIA MMIKNEDQRP HDYSDMDKFP RPSHADFTYS EKYGIKASSG 120
GGRASARETI GRVASGAIAE KFLAQNSNVE IVAFVTQIGE IKMNRDSFDP EFQHLLNTIT 180
REKVDSMGPI RCPDASVAGL MVKEIEKYRG NKDSIGGVVT CVVRNLPTGL GEPCFDKLEA 240
MLAHAMLSIP ASKGFEIGSG FQGVSVPGSK HNDPFYFEKE TNRLRTKTNN SGGVQGGISN 300
GENIYFSVPF KSVATISQEQ KTATYDGEEG ILAAKGRHDP AVTPRAIPIV EAMTALVLAD 360
ALLIQKARDF SRSVVH 376 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0004107; F:chorismate synthase activity; IMP:SGD.
 GO:0042602; F:riboflavin reductase (NADPH) activity; IDA:SGD.
 GO:0009073; P:aromatic amino acid family biosynthetic process; IMP:SGD.
 GO:0009423; P:chorismate biosynthetic process; TAS:SGD.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 
Interpro
 IPR000453; Chorismate_synth.
 IPR020541; Chorismate_synthase_CS. 
Pfam
 PF01264; Chorismate_synt 
SMART
  
PROSITE
 PS00787; CHORISMATE_SYNTHASE_1
 PS00788; CHORISMATE_SYNTHASE_2
 PS00789; CHORISMATE_SYNTHASE_3 
PRINTS