UniProt Accession

 TREM1_HUMAN; Q9NP99; B4DWG2; Q53FL8; Q5T2C9; Q86YU1 

Genbank Protein ID

 AF196329; AF287008; AY074783; AK301519; AL391903; BC017773; AK223264 

Genbank Nucleotide ID

 AAF71694.1; AAF90197.1; AAL74018.1; BAG63024.1; CAI19864.1; AAH17773.1; BAD96984.1 

Protein Name

 Triggering receptor expressed on myeloid cells 1 

Protein Synonyms/Alias

 TREM-1; Triggering receptor expressed on monocytes 1; CD354 

Gene Name

 TREM1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
120	CVIYQPPKEPHMLFD	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. 

Sequence Annotation

 DOMAIN 26 134 Ig-like V-type.
 CARBOHYD 146 146 N-linked (GlcNAc...) (Potential).
 CARBOHYD 191 191 N-linked (GlcNAc...) (Potential).
 CARBOHYD 194 194 N-linked (GlcNAc...) (Potential).
 DISULFID 41 113  

Keyword

 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Receptor; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 234 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0004872; F:receptor activity; TAS:ProtInc.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0006959; P:humoral immune response; TAS:ProtInc.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0035556; P:intracellular signal transduction; TAS:ProtInc.
 GO:0050900; P:leukocyte migration; TAS:Reactome. 

Interpro

 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set. 

Pfam

 PF07686; V-set 

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE 

PRINTS