CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028852
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Pyruvate dehydrogenase protein X component, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Pdhx 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
129AARNILEKHSLDASQacetylation[1, 2, 3]
148GPRGIFTKEDALKLVacetylation[3]
Reference
 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 218 AA 
Protein Sequence
RGASWRWFHS TQLLQGEAVS AGDSLCEIET DKAVVTLDAN DDGILAKIVV EEGAKNIQLG 60
SLIALMVEEG EDWKQVEIPK DVSAPPPVSK PPAPTQPSPQ PQIPCPARKE HKGTARFRLS 120
PAARNILEKH SLDASQGTAT GPRGIFTKED ALKLVELKQM GKITESRPAS APPPSLSASV 180
PPQATAGPSY PRPMTPPVSI PGQPNAAGTF TEIPASNI 218 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0016746; F:transferase activity, transferring acyl groups; IEA:InterPro. 
Interpro
 IPR003016; 2-oxoA_DH_lipoyl-BS.
 IPR000089; Biotin_lipoyl.
 IPR004167; E3-bd.
 IPR011053; Single_hybrid_motif. 
Pfam
 PF00364; Biotin_lipoyl
 PF02817; E3_binding 
SMART
  
PROSITE
 PS50968; BIOTINYL_LIPOYL
 PS00189; LIPOYL 
PRINTS