CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036885
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Disintegrin and metalloproteinase domain-containing protein 19 
Protein Synonyms/Alias
  
Gene Name
 ADAM19 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
290SFLSWRRKLLAQKYHubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 920 AA 
Protein Sequence
MPGGAGAARL CLLAFALQPL RPRAAREPGW TISRGSEEGS PKLQHELIIP QWKTSESPVR 60
EKHPLKAELR VMAEGRELIL DLEKNEQLFA PSYTETHYTS SGNPQTTTRK LEDHCFYHGT 120
VRETELSSVT LSTCRGIRGL ITVSSNLSYV IEPLPDSKGQ HLIYRSEHLK PPPGNCGFEH 180
SKPTTRDWAL QFTQQTKKRP RRMKREDLNS MKYVELYLVA DYLEFQKNRR DQDATKHKLI 240
EIANYVDKFY RSLNIRIALV GLEVWTHGNM CEVSENPYST LWSFLSWRRK LLAQKYHDNA 300
QLITGMSFHG TTIGLAPLMA MCSVYQSGGV NMDHSENAIG VAATMAHEMG HNFGMTHDSA 360
DCCSASAADG GCIMAAATGH PFPKVFNGCN RRELDRYLQS GGGMCLSNMP DTRMLYGGRR 420
CGNGYLEDGE ECDCGEEEEC NNPCCNASNC TLRPGAECAH GSCCHQCKLL APGTLCREQA 480
RQCDLPEFCT GKSPHCPTNF YQMDGTPCEG GQAYCYNGMC LTYQEQCQQL WGPGARPAPD 540
LCFEKVNVAG DTFGNCGKDM NGEHRKCNMR DAKCGKIQCQ SSEARPLESN AVPIDTTIIM 600
NGRQIQCRGT HVYRGPEEEG DMLDPGLVMT GTKCGYNHIC FEGQCRNTSF FETEGCGKKC 660
NGHGVCNNNQ NCHCLPGWAP PFCNTPGHGG SIDSGPMPPE SVGPVVAGVL VAILVLAVLM 720
LMYYCCRQNN KLGQLKPSAL PSKLRQQFSC PFRVSQNSGT GHANPTFKLQ TPQGKRKVIN 780
TPEILRKPSQ PPPRPPPDYL RGGSPPAPLP AHLSRAARNS PGPGSQIERT ESSRRPPPSR 840
PIPPAPNCIV SQDFSRPRPP QKALPANPVP GRRSLPRPGG ASPLRPPGAG PQQSRPLAAL 900
APKFPEYRSQ RAGGMISSKI 920 
Gene Ontology
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR006586; ADAM_Cys-rich.
 IPR001762; Blood-coag_inhib_Disintegrin.
 IPR018358; Disintegrin_CS.
 IPR000742; EG-like_dom.
 IPR013032; EGF-like_CS.
 IPR024079; MetalloPept_cat_dom.
 IPR001590; Peptidase_M12B.
 IPR002870; Peptidase_M12B_N. 
Pfam
 PF08516; ADAM_CR
 PF00200; Disintegrin
 PF01562; Pep_M12B_propep
 PF01421; Reprolysin 
SMART
 SM00608; ACR
 SM00050; DISIN 
PROSITE
 PS50215; ADAM_MEPRO
 PS00427; DISINTEGRIN_1
 PS50214; DISINTEGRIN_2
 PS01186; EGF_2
 PS50026; EGF_3 
PRINTS
 PR00289; DISINTEGRIN.