CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000934
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable phospholipid-transporting ATPase IK 
Protein Synonyms/Alias
 ATPase class I type 8B member 3 
Gene Name
 ATP8B3 
Gene Synonyms/Alias
 ATP1K; FOS37502_2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
108RNSAFTWKVQANNRAubiquitination[1]
123YNGQFKEKVILCWQRubiquitination[1]
225PCQILMGKSFKQKKWubiquitination[1]
231GKSFKQKKWQDLCVGubiquitination[1]
296KELATIKKMASFQGTubiquitination[1]
326CLEWNDKKYSLDIGNubiquitination[1]
496VEYIFSDKTGTLTQNubiquitination[1]
509QNILTFNKCCISGRVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 ACT_SITE 495 495 4-aspartylphosphate intermediate (By
 METAL 939 939 Magnesium (By similarity).
 METAL 943 943 Magnesium (By similarity).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Hydrolase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1300 AA 
Protein Sequence
MGTGPAQTPR STRAGPEPSP APPGPGDTGD SDVTQEGSGP AGIRGGETVI RAGMGDSPGR 60
GAPERRHKAQ PGRARKYEWR PEGPTSMGSL GQREDLQDED RNSAFTWKVQ ANNRAYNGQF 120
KEKVILCWQR KKYKTNVIRT AKYNFYSFLP LNLYEQFHRV SNLFFLIIII LQSIPDISTL 180
PWFSLSTPMV CLLFIRATRD LVDDMGRHKS DRAINNRPCQ ILMGKSFKQK KWQDLCVGDV 240
VCLRKDNIVP ADMLLLASTE PSSLCYVETV DIDGETNLKF RQALMVTHKE LATIKKMASF 300
QGTVTCEAPN SRMHHFVGCL EWNDKKYSLD IGNLLLRGCR IRNTDTCYGL VIYAGFDTKI 360
MKNCGKIHLK RTKLDLLMNK LVVVIFISVV LVCLVLAFGF GFSVKEFKDH HYYLSGVHGS 420
SVAAESFFVF WSFLILLSVT IPMSMFILSE FIYLGNSVFI DWDVQMYYKP QDVPAKARST 480
SLNDHLGQVE YIFSDKTGTL TQNILTFNKC CISGRVYGPD SEATTRPKEN PYLWNKFADG 540
KLLFHNAALL HLVRTNGDEA VREFWRLLAI CHTVMVRESP RERPDQLLYQ AASPDEGALV 600
TAARNFGYVF LSRTQDTVTI MELGEERVYQ VLAIMDFNST RKRMSVLVRK PEGAICLYTK 660
GADTVIFERL HRRGAMEFAT EEALAAFAQE TLRTLCLAYR EVAEDIYEDW QQRHQEASLL 720
LQNRAQALQQ VYNEMEQDLR LLGATAIEDR LQDGVPETIK CLKKSNIKIW VLTGDKQETA 780
VNIGFACELL SENMLILEEK EISRILETYW ENSNNLLTRE SLSQVKLALV INGDFLDKLL 840
VSLRKEPRAL AQNVNMDEAW QELGQSRRDF LYARRLSLLC RRFGLPLAAP PAQDSRARRS 900
SEVLQERAFV DLASKCQAVI CCRVTPKQKA LIVALVKKYH QVVTLAIGDG ANDINMIKTA 960
DVGVGLAGQE GMQAVQNSDF VLGQFCFLQR LLLVHGRWSY VRICKFLRYF FYKSMASMMV 1020
QVWFACYNGF TGQPLYEGWF LALFNLLYST LPVLYIGLFE QDVSAEQSLE KPELYVVGQK 1080
DELFNYWVFV QAIAHGVTTS LVNFFMTLWI SRDTAGPASF SDHQSFAVVV ALSCLLSITM 1140
EVILIIKYWT ALCVATILLS LGFYAIMTTT TQSFWLFRVS PTTFPFLYAD LSVMSSPSIL 1200
LVVLLSVSIN TFPVLALRVI FPALKELRAK EEKVEEGPSE EIFTMEPLPH VHRESRARRS 1260
SYAFSHREGY ANLITQGTIL RRGPGVSSDI ASESLDPSDE EAASSPKESQ 1310 
Gene Ontology
 GO:0001669; C:acrosomal vesicle; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0019829; F:cation-transporting ATPase activity; IEA:InterPro.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0004012; F:phospholipid-translocating ATPase activity; IEA:EC.
 GO:0007339; P:binding of sperm to zona pellucida; IEA:Compara.
 GO:0045332; P:phospholipid translocation; IEA:Compara. 
Interpro
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR018303; ATPase_P-typ_P_site.
 IPR006539; ATPase_P-typ_Plipid-transp.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom. 
Pfam
 PF00122; E1-E2_ATPase 
SMART
  
PROSITE
 PS00154; ATPASE_E1_E2 
PRINTS
 PR00119; CATATPASE.