UniProt Accession

 SRF1_YEAST; Q12516; D6VRL6; P89897; Q7LGS2 

Genbank Protein ID

 X96876; Z74180; Z74181; BK006938 

Genbank Nucleotide ID

 CAA65627.1; CAA98703.1; CAA98704.1; DAA11726.1 

Protein Name

 Regulator of phospholipase D SRF1 

Protein Synonyms/Alias

 SPO14 regulatory factor 1 

Gene Name

 SRF1 

Gene Synonyms/Alias

 YDL133W; D2185 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
36	NLNVDLEKNQTVRKS	ubiquitination	[1]
42	EKNQTVRKSGSLEAL	ubiquitination	[1]
97	DKLRLQDKGTVDGNV	ubiquitination	[1]
108	DGNVTDDKNLPKEFK	ubiquitination	[1]
154	LSSSTSSKNAALREI	ubiquitination	[1]
206	LQYIEKVKDFYYGDN	acetylation	[2]
214	DFYYGDNKKNPESPE	acetylation	[2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] mChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases.
 Mitchell L, Huard S, Cotrut M, Pourhanifeh-Lemeri R, Steunou AL, Hamza A, Lambert JP, Zhou H, Ning Z, Basu A, Côté J, Figeys DA, Baetz K.
 Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1641-50. [PMID: 23572591] 

Functional Description

 Regulator of phospholipase D (SPO14) which is required for SPO14 catalytic activity in mitotic cells. Essential to buffer the toxic effects of C16:0 platelet activating factor. 

Sequence Annotation

 MOD_RES 45 45 Phosphoserine.
 MOD_RES 167 167 Phosphoserine.
 CARBOHYD 297 297 N-linked (GlcNAc...) (Potential).
 CARBOHYD 385 385 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Glycoprotein; Lipid degradation; Lipid metabolism; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 437 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
 GO:0043085; P:positive regulation of catalytic activity; IMP:SGD. 

Interpro

  

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PRINTS