| Tag | Content |
|---|
| CPLM ID | CPLM-024605 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Integrin beta-1 |
Protein Synonyms/Alias | Fibronectin receptor subunit beta; Integrin subunit beta-1; VLA-4 subunit beta; CD29 |
Gene Name | ITGB1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Ovis aries (Sheep) |
NCBI Taxa ID | 9940 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 784 | TGENPIYKSAVTTVV | ubiquitination | [1] |
|
Reference | [1] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML. Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [ PMID: 21139048] |
Functional Description | Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1, serves as a platform for SRC activation or inactivation (By similarity). Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (By similarity). |
Sequence Annotation | DOMAIN 140 378 VWFA.
REPEAT 466 515 I.
REPEAT 516 559 II.
REPEAT 560 598 III.
REPEAT 599 635 IV.
REGION 466 635 Cysteine-rich tandem repeats.
REGION 785 792 Interaction with ITGB1BP1 (By
METAL 152 152 Magnesium (By similarity).
METAL 154 154 Calcium 1; via carbonyl oxygen (By
METAL 156 156 Calcium 1 (By similarity).
METAL 157 157 Calcium 1 (By similarity).
METAL 189 189 Calcium 2 (By similarity).
METAL 244 244 Calcium 2 (By similarity).
METAL 246 246 Calcium 2 (By similarity).
METAL 248 248 Calcium 2; via carbonyl oxygen (By
METAL 249 249 Calcium 2 (By similarity).
METAL 249 249 Magnesium (By similarity).
METAL 362 362 Calcium 1; via carbonyl oxygen (By
MOD_RES 186 186 Phosphoserine (By similarity).
MOD_RES 777 777 Phosphothreonine (By similarity).
MOD_RES 783 783 Phosphotyrosine (By similarity).
MOD_RES 794 794 N6-acetyllysine (By similarity).
CARBOHYD 50 50 N-linked (GlcNAc...) (Potential).
CARBOHYD 94 94 N-linked (GlcNAc...) (Potential).
CARBOHYD 97 97 N-linked (GlcNAc...) (Potential).
CARBOHYD 212 212 N-linked (GlcNAc...) (Potential).
CARBOHYD 406 406 N-linked (GlcNAc...) (Potential).
CARBOHYD 417 417 N-linked (GlcNAc...) (Potential).
CARBOHYD 481 481 N-linked (GlcNAc...) (Potential).
CARBOHYD 520 520 N-linked (GlcNAc...) (Potential).
CARBOHYD 584 584 N-linked (GlcNAc...) (Potential).
CARBOHYD 669 669 N-linked (GlcNAc...) (Potential).
DISULFID 27 45 By similarity.
DISULFID 35 464 By similarity.
DISULFID 38 75 By similarity.
DISULFID 48 64 By similarity.
DISULFID 207 213 By similarity.
DISULFID 261 301 By similarity.
DISULFID 401 415 By similarity.
DISULFID 435 462 By similarity.
DISULFID 466 691 By similarity.
DISULFID 477 489 By similarity.
DISULFID 486 525 By similarity.
DISULFID 491 500 By similarity.
DISULFID 502 516 By similarity.
DISULFID 531 536 By similarity.
DISULFID 533 568 By similarity.
DISULFID 538 553 By similarity.
DISULFID 555 560 By similarity.
DISULFID 574 579 By similarity.
DISULFID 576 607 By similarity.
DISULFID 581 590 By similarity.
DISULFID 592 599 By similarity.
DISULFID 613 618 By similarity.
DISULFID 615 661 By similarity.
DISULFID 620 630 By similarity.
DISULFID 633 636 By similarity.
DISULFID 640 649 By similarity.
DISULFID 646 723 By similarity.
DISULFID 665 699 By similarity. |
Keyword | Acetylation; Cell adhesion; Cell membrane; Cell projection; Disulfide bond; Glycoprotein; Integrin; Magnesium; Membrane; Metal-binding; Phosphoprotein; Receptor; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 798 AA |
Protein Sequence | MNLQLIFWIG LISSVCCVFG QADENRCLKA NAKSCGECIQ AGPNCGWCTN STFLQEGMPT 60
SARCDDLEAL KKKGCHPNDI ENPRGSKDIK KNKNVTNRSK GTAEKLQPED ITQIQPQQLV 120
LQLRSGEPQT FTLKFKRAED YPIDLYYLMD LSYSMKDDLE NVKSLGTDLM NEMRRITSDF 180
RIGFGSFVEK TVMPYISTTP AKLRNPCTNE QNCTSPFSYK NVLSLTDKGE VFNELVGKQR 240
ISGNLDSPEG GFDAIMQVAV CGSLIGWRNV TRLLVFSTDA GFHFAGDGKL GGIVLPNDGQ 300
CHLENDMYTM SHYYDYPSIA HLVQKLSENN IQTIFAVTEE FQPVYKELKN LIPKSAVGTL 360
SANSGNVIQL IIDAYNSLSS EVILENSKLP EGVTINYKSY CKNGVNGTGE NGRKCSNISI 420
GDEVQFEISI TANKCPNKNS ETIKIKPLGF TEEVEIILQF ICECECQSEG IPGSPKCHDG 480
NGTFECGACR CNEGRVGRHC ECSTDEVNSE DMDAYCRKEN SSEICSNNGE CVCGQCVCRK 540
RDNTNEIYSG KFCECDNFNC DRSNGLICGG NGVCKCRVCE CNPNYTGSAC DCSLDTTSCM 600
AVNGQICNGR GVCECGACKC TDPKFQGPTC EMCQTCLGVC AEHKECVQCR AFNKGEKKDT 660
CAQECSHFNI TKVENRDKLP QPGQVDPLSH CKEKDVDDCW FYFTYSVNGN NEATVHVVET 720
PECPTGPDII PIVAGVVAGI VLIGPALLLI WKLLMIIHDR REFAKFEKEK MNAKWDTGEN 780
PIYKSAVTTV VNPKYEGK 798 |
Gene Ontology | GO:0008305; C:integrin complex; IEA:InterPro. GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell. GO:0042470; C:melanosome; IEA:UniProtKB-SubCell. GO:0001726; C:ruffle; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004872; F:receptor activity; IEA:InterPro. GO:0007160; P:cell-matrix adhesion; IEA:InterPro. GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW. GO:0007275; P:multicellular organismal development; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |