CPLM-014357

Genbank Nucleotide ID

Glycerol-3-phosphate acyltransferase 1, mitochondrial

Protein Synonyms/Alias

Mus musculus (Mouse)

Position	Peptide	Type	References
40	DWVDCGFKPTFFRSA	ubiquitination	[1]
391	GVIRMLRKNYGYVRV	ubiquitination	[1]
779	SATYCLVKNAVKMFK	acetylation	[2, 3, 4, 5]
783	CLVKNAVKMFKDIGV	acetylation	[3, 4, 5]

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
[2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
Simon GM, Cheng J, Gordon JI.
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
[3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
[4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
[5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
J Biol Chem. 2013 Jul 17;. [PMID: 23864654]

Functional Description

Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis (By similarity).

MOTIF 230 235 HXXXXD motif.
MOD_RES 380 380 Phosphoserine (By similarity).
MOD_RES 694 694 Phosphoserine.

Acyltransferase; Complete proteome; Lipid biosynthesis; Lipid metabolism; Membrane; Mitochondrion; Mitochondrion outer membrane; Phospholipid biosynthesis; Phospholipid metabolism; Phosphoprotein; Reference proteome; Transferase; Transit peptide; Transmembrane; Transmembrane helix.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
GO:0004366; F:glycerol-3-phosphate O-acyltransferase activity; IDA:MGI.
GO:0006637; P:acyl-CoA metabolic process; IMP:MGI.
GO:0016024; P:CDP-diacylglycerol biosynthetic process; IEA:UniProtKB-UniPathway.
GO:0051607; P:defense response to virus; IMP:MGI.
GO:0055089; P:fatty acid homeostasis; IMP:MGI.
GO:0006631; P:fatty acid metabolic process; IMP:MGI.
GO:0006650; P:glycerophospholipid metabolic process; IMP:MGI.
GO:0070970; P:interleukin-2 secretion; IMP:MGI.
GO:0070236; P:negative regulation of activation-induced cell death of T cells; IMP:MGI.
GO:0055091; P:phospholipid homeostasis; IMP:MGI.
GO:0042104; P:positive regulation of activated T cell proliferation; IMP:MGI.
GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI.
GO:0050707; P:regulation of cytokine secretion; IMP:MGI.
GO:0009749; P:response to glucose stimulus; IMP:MGI.
GO:0019432; P:triglyceride biosynthetic process; IEA:Compara.
GO:0006641; P:triglyceride metabolic process; IMP:MGI.

IPR022284; G3P_O-AcylTrfase.
IPR002123; Plipid/glycerol_acylTrfase.

PF01553; Acyltransferase