UniProt Accession

 GNA11_MOUSE; P21278; Q61939 

Genbank Protein ID

 M55411; U37413; U37411; U37412; M57617 

Genbank Nucleotide ID

 AAA63305.1; AAB36839.1; AAB36839.1; AAB36839.1; AAA63301.1 

Protein Name

 Guanine nucleotide-binding protein subunit alpha-11 

Protein Synonyms/Alias

 G alpha-11; G-protein subunit alpha-11 

Gene Name

 Gna11 

Gene Synonyms/Alias

 Gna-11 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
27	RINAEIEKQLRRDKR	ubiquitination	[1]
52	LGTGESGKSTFIKQM	ubiquitination	[1]
72	AGYSEEDKRGFTKLV	ubiquitination	[1]
102	ETLKILYKYEQNKAN	ubiquitination	[1]
107	LYKYEQNKANALLIR	ubiquitination	[1]
120	IREVDVEKVTTFEHQ	ubiquitination	[1]
158	FQLSDSAKYYLTDVD	ubiquitination	[1]
252	ENRMEESKALFRTII	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. 

Sequence Annotation

 NP_BIND 46 53 GTP (By similarity).
 NP_BIND 180 186 GTP (By similarity).
 NP_BIND 205 209 GTP (By similarity).
 NP_BIND 274 277 GTP (By similarity).
 METAL 53 53 Magnesium (By similarity).
 METAL 186 186 Magnesium (By similarity).
 BINDING 331 331 GTP; via amide nitrogen (By similarity).
 LIPID 9 9 S-palmitoyl cysteine (By similarity).
 LIPID 10 10 S-palmitoyl cysteine (By similarity).  

Keyword

 Cell membrane; Complete proteome; Direct protein sequencing; GTP-binding; Lipoprotein; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Palmitate; Reference proteome; Transducer. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 359 AA 

Protein Sequence

Gene Ontology

 GO:0005834; C:heterotrimeric G-protein complex; ISA:MGI.
 GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome.
 GO:0001664; F:G-protein coupled receptor binding; IBA:RefGenome.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; ISA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004871; F:signal transducer activity; IBA:RefGenome.
 GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IBA:RefGenome.
 GO:0048066; P:developmental pigmentation; IMP:MGI.
 GO:0007507; P:heart development; IMP:MGI.
 GO:0060158; P:phospholipase C-activating dopamine receptor signaling pathway; IGI:MGI.
 GO:0001508; P:regulation of action potential; IDA:MGI.
 GO:0045634; P:regulation of melanocyte differentiation; IMP:MGI.
 GO:0001501; P:skeletal system development; IMP:MGI. 

Interpro

 IPR000654; Gprotein_alpha_Q.
 IPR001019; Gprotein_alpha_su.
 IPR011025; GproteinA_insert.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00503; G-alpha 

SMART

 SM00275; G_alpha 

PROSITE

  

PRINTS

 PR00318; GPROTEINA.
 PR00442; GPROTEINAQ.