CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022257
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane protein 45A 
Protein Synonyms/Alias
 DNA polymerase-transactivated protein 4; Dermal papilla-derived protein 7 
Gene Name
 TMEM45A 
Gene Synonyms/Alias
 DERP7; DNAPTP4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
43RTCYLGSKTLFYRLEubiquitination[1, 2]
263SSEVGLLKNAEREQEubiquitination[1, 2, 3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
  
Sequence Annotation
 MOD_RES 271 271 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 275 AA 
Protein Sequence
MGNFRGHALP GTFFFIIGLW WCTKSILKYI CKKQKRTCYL GSKTLFYRLE ILEGITIVGM 60
ALTGMAGEQF IPGGPHLMLY DYKQGHWNQL LGWHHFTMYF FFGLLGVADI LCFTISSLPV 120
SLTKLMLSNA LFVEAFIFYN HTHGREMLDI FVHQLLVLVV FLTGLVAFLE FLVRNNVLLE 180
LLRSSLILLQ GSWFFQIGFV LYPPSGGPAW DLMDHENILF LTICFCWHYA VTIVIVGMNY 240
AFITWLVKSR LKRLCSSEVG LLKNAEREQE SEEEM 275 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR006904; DUF716_TMEM45. 
Pfam
 PF04819; DUF716 
SMART
  
PROSITE
  
PRINTS