UniProt Accession

 SPEE_ECOLI; P09158 

Genbank Protein ID

 J02804; U00096; AP009048 

Genbank Nucleotide ID

 AAA24643.1; AAC73232.1; BAB96695.1 

Protein Name

 Spermidine synthase 

Protein Synonyms/Alias

 Putrescine aminopropyltransferase; PAPT; SPDSY 

Gene Name

 speE 

Gene Synonyms/Alias

 b0121; JW0117 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
260	RFLASGLKCRYYNPA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor. 

Sequence Annotation

 REGION 140 141 S-adenosylmethioninamine binding (By
 ACT_SITE 158 158 Proton acceptor (By similarity).
 BINDING 33 33 S-adenosylmethioninamine (By similarity).
 BINDING 63 63 Putrescine (By similarity).
 BINDING 88 88 S-adenosylmethioninamine (By similarity).
 BINDING 108 108 S-adenosylmethioninamine (By similarity).
 BINDING 161 161 Putrescine (By similarity).
 BINDING 226 226 Putrescine (By similarity).  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Polyamine biosynthesis; Reference proteome; Spermidine biosynthesis; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 288 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0004766; F:spermidine synthase activity; IDA:EcoCyc.
 GO:0008295; P:spermidine biosynthetic process; IMP:EcoCyc. 

Interpro

 IPR001045; Spermidine/spermine_synthase. 

Pfam

 PF01564; Spermine_synth 

SMART

  

PROSITE

 PS01330; SPERMIDINE_SYNTHASE_1
 PS51006; SPERMIDINE_SYNTHASE_2 

PRINTS