UniProt Accession

 SCMC1_MOUSE; Q8BMD8; Q3TCQ2; Q3THY3; Q7TPC2 

Genbank Protein ID

 AK032806; AK146034; AK167778; AK168090; AK170598; AL671921; AL845310; AL845310; AL671921; CT010461; BC055369 

Genbank Nucleotide ID

 BAC28031.1; BAE26847.1; BAE39810.1; BAE40063.1; BAE41903.1; CAM19805.1; CAM19805.1; CAM26535.1; CAM26535.1; CAM28161.1; AAH55369.1 

Protein Name

 Calcium-binding mitochondrial carrier protein SCaMC-1 

Protein Synonyms/Alias

 Small calcium-binding mitochondrial carrier protein 1; Solute carrier family 25 member 24 

Gene Name

 Slc25a24 

Gene Synonyms/Alias

 Scamc1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
318	KTRLAVAKTGQYSGI	acetylation	[1]
318	KTRLAVAKTGQYSGI	succinylation	[1]
334	GCAKKILKHEGFGAF	acetylation	[2, 3, 4, 5]
435	LFQRIVSKEGVSGLY	acetylation	[1, 2, 3]
435	LFQRIVSKEGVSGLY	succinylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity). 

Sequence Annotation

 DOMAIN 19 54 EF-hand 1.
 DOMAIN 55 88 EF-hand 2.
 DOMAIN 86 121 EF-hand 3.
 DOMAIN 122 157 EF-hand 4.
 REPEAT 192 276 Solcar 1.
 REPEAT 284 369 Solcar 2.
 REPEAT 381 469 Solcar 3.
 MOD_RES 334 334 N6-acetyllysine (By similarity).
 MOD_RES 435 435 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Calcium; Complete proteome; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 475 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0055085; P:transmembrane transport; IEA:InterPro. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR002167; Graves_DC.
 IPR002067; Mit_carrier.
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 

Pfam

 PF13499; EF_hand_5
 PF00153; Mito_carr 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50920; SOLCAR 

PRINTS

 PR00928; GRAVESDC.
 PR00926; MITOCARRIER.