CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027049
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CAMP-dependent protein kinase regulatory subunit, putative 
Protein Synonyms/Alias
  
Gene Name
 PKAr 
Gene Synonyms/Alias
 PFL1110c 
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
145ESIHFIQKKRLSVSAacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 441 AA 
Protein Sequence
MGNVCTWRQG KEKAGDDNSQ VIKDKELQNE FKTFEQKMRS NKKNAHEGDM NNDGEDDRYK 60
FSRGFSLSKK PSKTKIPITK TDSEILDGLD YSEMSKQVLM TLNKKNILND DGSSDGNDTD 120
VHSMFDRKEI ERKVLDLESI HFIQKKRLSV SAEAYGDWNK KIDNFIPKVY KKDEKEKAKI 180
REALNESFLF NHLNKKEFEI IVNAFFDKNV EKGVNIINEG DYGDLLYVID QGEVEIYKTK 240
ENNKKEVLTV LKSKDVFGEL ALLYNSKRAA TATALTKCHL WALDRESFTY IIKDMVAKKR 300
KMYEDILSHV NILKDMDPYE RCKVADCLKS KSYNDGEIII KEGEEGDTFF ILIDGNAVAS 360
KDNKVIKTYT KGDYFGELAL LKNKPRAATI KAQNFCQVVY LDRKSFKRLL GPIEDILHRN 420
VENYKKVLNE LGLDTTCIDE N 441 
Gene Ontology
 GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro.
 GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR002373; cAMP/cGMP_kin.
 IPR012198; cAMP_dep_PK_reg_su.
 IPR018490; cNMP-bd-like.
 IPR018488; cNMP-bd_CS.
 IPR000595; cNMP-bd_dom.
 IPR014710; RmlC-like_jellyroll. 
Pfam
 PF00027; cNMP_binding 
SMART
 SM00100; cNMP 
PROSITE
 PS00888; CNMP_BINDING_1
 PS00889; CNMP_BINDING_2
 PS50042; CNMP_BINDING_3 
PRINTS
 PR00103; CAMPKINASE.