CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037432
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Poly [ADP-ribose] polymerase 8 
Protein Synonyms/Alias
  
Gene Name
 PARP8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
406LYGLKNHKLLSKSYSubiquitination[1]
410KNHKLLSKSYSSAPKubiquitination[1]
420SSAPKSSKTELFKEPubiquitination[1]
586KNYDRVMKALDSITSubiquitination[1]
633SNRSHIVKLPVNRQLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 833 AA 
Protein Sequence
MEPAALRCAY FRYSDSTFTF TYVGGPRSVS YSVHVSEDYP DNTYVSSSEN DEDVLVTTEP 60
IPVIFHRIAT ELRKTNDINC CLSIKSKLQK ENGEESRQNS TVEEDSEGDN DSEEFYYGGQ 120
VNYDGELHKH PQLEADLSAV REIYGPHAVS LREYGAIDDV DIDLHIDVSF LDEEIAVAWE 180
VIRTEPIIVR LHCSLTQYLN GPVPTVDVFQ ISTKERFGLG HQLKKIMQTF VTQQWKQSKE 240
KSNCLHNKKL SEKKVKSPLH LFSTLRRSPS YPPPGCGKSK SKLKSEQDGI SKTHKLLRRT 300
CSSTVKTDDV CVTKSHRTFG RSLSSDPRAE QAMTAIKSHK LLNRPCPAAV KSEECLTLKS 360
HRLLTRSCSG DPRCEHNTNL KPHKLLSRSY SSNLRMEELY GLKNHKLLSK SYSSAPKSSK 420
TELFKEPNAE GRRLSLTSGL IGILTPSSSS SSQLAPNGAK CIPVRDRGFL VQTIEFAEQR 480
IPVLNEYCVV CDEPHVFQNG PMLRPTVCER ELCVFAFQTL GVMNEAADEI ATGAQVVDLL 540
VSMCRSALES PRKVVIFEPY PSVVDPNDPQ MLAFNPRKKN YDRVMKALDS ITSIREMTQA 600
PYLEIKKQMD KQDPLAHPLL QWVISSNRSH IVKLPVNRQL KFMHTPHQFL LLSSPPAKES 660
NFRAAKKLFG STFAFHGSHI ENWHSILRNG LVVASNTRLQ LHGAMYGSGI YLSPMSSISF 720
GYSGMNKKQK VSAKDEPASS SKSSNTSQSQ KKGQQSQFLQ SRNLKCIALC EVITSSDLHK 780
HGEIWVVPNT DHVCTRFFFV YEDGQVGDAN INTQEGGIHK EILRVIGNQT ATG 833 
Gene Ontology
 GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:InterPro. 
Interpro
 IPR012317; Poly(ADP-ribose)pol_cat_dom. 
Pfam
 PF00644; PARP 
SMART
  
PROSITE
 PS51059; PARP_CATALYTIC 
PRINTS