UniProt Accession

 CYBP_RAT; Q6AYK6 

Genbank Protein ID

 BC079007 

Genbank Nucleotide ID

 AAH79007.1 

Protein Name

 Calcyclin-binding protein 

Protein Synonyms/Alias

 CacyBP 

Gene Name

 Cacybp 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
86	YGWDQSDKFVKIYIT	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity). 

Sequence Annotation

 DOMAIN 74 168 CS.
 DOMAIN 169 229 SGS.
 REGION 2 81 Interaction with SIAH1 (By similarity).
 REGION 74 229 Interaction with SKP1 (By similarity).
 REGION 155 229 Interaction with S100A6 (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 10 10 N6-acetyllysine (By similarity).
 MOD_RES 21 21 N6-acetyllysine (By similarity).
 MOD_RES 86 86 N6-acetyllysine (By similarity).
 MOD_RES 119 119 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 229 AA 

Protein Sequence

Gene Ontology

 GO:0030877; C:beta-catenin destruction complex; IEA:Compara.
 GO:0044297; C:cell body; IDA:RGD.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0043005; C:neuron projection; IDA:RGD.
 GO:0005641; C:nuclear envelope lumen; IEA:Compara.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0007568; P:aging; IEP:RGD.
 GO:0055007; P:cardiac muscle cell differentiation; IDA:RGD.
 GO:0071277; P:cellular response to calcium ion; IEP:RGD.
 GO:0060548; P:negative regulation of cell death; IDA:RGD.
 GO:0045740; P:positive regulation of DNA replication; IDA:RGD.
 GO:0060416; P:response to growth hormone stimulus; IMP:RGD. 

Interpro

 IPR007052; CS-like_domain.
 IPR017447; CS_domain.
 IPR008978; HSP20-like_chaperone.
 IPR007699; SGS.
 IPR015120; Siah-Interact_N. 

Pfam

 PF04969; CS
 PF05002; SGS
 PF09032; Siah-Interact_N 

SMART

  

PROSITE

 PS51203; CS
 PS51048; SGS 

PRINTS