UniProt Accession

 ARP3B_HUMAN; Q9P1U1; A8MTG1; B4DFW4; Q7Z526; Q96BT2 

Genbank Protein ID

 AF023453; AF086920; AK294292; AK315534; AC072057; AC092180; BC015207; BC008682 

Genbank Nucleotide ID

 AAC98904.1; AAP97150.1; BAG57575.1; BAG37914.1; AAH15207.1; AAH08682.1 

Protein Name

 Actin-related protein 3B 

Protein Synonyms/Alias

 ARP3-beta; Actin-like protein 3B; Actin-related protein ARP4 

Gene Name

 ACTR3B 

Gene Synonyms/Alias

 ARP11; ARP4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
69	IGDEAIDKPTYATKW	ubiquitination	[1]
266	INAINQKKFVIDVGY	ubiquitination	[2]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 240 240 N6-acetyllysine (By similarity).
 MOD_RES 244 244 N6-acetyllysine (By similarity).
 MOD_RES 251 251 N6-acetyllysine (By similarity).
 MOD_RES 254 254 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Actin-binding; Alternative splicing; ATP-binding; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Nucleotide-binding; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 418 AA 

Protein Sequence

Gene Ontology

 GO:0005885; C:Arp2/3 protein complex; IEA:InterPro.
 GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro. 

Interpro

 IPR004000; Actin-related.
 IPR020902; Actin/actin-like_CS.
 IPR015623; Arp3. 

Pfam

 PF00022; Actin 

SMART

 SM00268; ACTIN 

PROSITE

 PS01132; ACTINS_ACT_LIKE 

PRINTS