CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000629
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Apoptosis inhibitor 5 
Protein Synonyms/Alias
 API-5; AAC-11 
Gene Name
 Api5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
51LAAQFIPKFFKHFPEacetylation[1]
84SIRRQAIKELPQFATubiquitination[2]
153IVRERAIKFLSTKLKacetylation[1]
160KFLSTKLKTLPDEVLubiquitination[2]
169LPDEVLTKEVEELILubiquitination[2]
202MKILSGLKSLQTVSGacetylation[1]
302SFCGDMEKLETNLRKacetylation[1]
444STVTLSWKPVQKVEIacetylation[1]
448LSWKPVQKVEIGQKRacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis (By similarity). 
Sequence Annotation
 REGION 2 360 ARM-like and Heat-like helical repeats
 REGION 370 391 Leucine-zipper.
 MOTIF 454 475 Nuclear localization signal (By
 MOD_RES 251 251 N6-acetyllysine (By similarity).
 MOD_RES 462 462 Phosphoserine (By similarity).
 MOD_RES 464 464 Phosphoserine (By similarity).  
Keyword
 Acetylation; Apoptosis; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 504 AA 
Protein Sequence
MPTVEELYRN YGILADATEQ VGQHKDAYQV ILDGVKGGTK EKRLAAQFIP KFFKHFPELA 60
DSAINAQLDL CEDEDVSIRR QAIKELPQFA TGENLPRVAD ILTQLLQTDD SAEFNLVNNA 120
LLSIFKMDAK GTLGGLFSQI LQGEDIVRER AIKFLSTKLK TLPDEVLTKE VEELILTESK 180
KVLEDVTGEE FVLFMKILSG LKSLQTVSGR QQLVELVAEQ ADLEQAFSPS DPDCVDRLLQ 240
CTRQAVPLFS KNVHSTRFVT YFCEQVLPNL STLTTPVEGL DIQLEVLKLL AEMSSFCGDM 300
EKLETNLRKL FDKLLEYMPL PPEEAENGEN AGNEEPKLQF SYVECLLYSF HQLGRKLPDF 360
LTAKLNAEKL KDFKIRLQYF ARGLQVYIRQ LRLALQGKTG EALKTEENKI KVVALKITNN 420
INVLIKDLFH IPPSYKSTVT LSWKPVQKVE IGQKRTSEDT SSGSPPKKSP GGPKRDARQI 480
YNPPSGKYSS NLSNFNYERS LQGK 504 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005681; C:spliceosomal complex; IDA:MGI.
 GO:0017134; F:fibroblast growth factor binding; ISS:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI. 
Interpro
 IPR008383; API5.
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold. 
Pfam
 PF05918; API5 
SMART
  
PROSITE
  
PRINTS