UniProt Accession

 PHF5A_RAT; P83871 

Genbank Protein ID

 AF495522 

Genbank Nucleotide ID

 AAM14623.1 

Protein Name

 PHD finger-like domain-containing protein 5A 

Protein Synonyms/Alias

 PHD finger-like domain protein 5A; Splicing factor 3B-associated 14 kDa protein; SF3b14b 

Gene Name

 Phf5a 

Gene Synonyms/Alias

 Ini 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
3	*****MAKHHPDLIF	acetylation	[1]
108	ERKKYGFKKR*****	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER- alpha. Also involved in pre-mRNA splicing. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 3 3 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; DNA-binding; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 110 AA 

Protein Sequence

Gene Ontology

 GO:0016363; C:nuclear matrix; IEA:Compara.
 GO:0016607; C:nuclear speck; ISS:UniProtKB.
 GO:0005689; C:U12-type spliceosomal complex; IEA:Compara.
 GO:0005686; C:U2 snRNP; ISS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR005345; PHF5. 

Pfam

 PF03660; PHF5 

SMART

  

PROSITE

  

PRINTS