| Tag | Content |
|---|
| CPLM ID | CPLM-016687 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Autophagy-related protein 16-1 |
Protein Synonyms/Alias | APG16-like 1 |
Gene Name | Atg16l1 |
Gene Synonyms/Alias | Apg16l |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 513 | CSRDDLLKVIDLRTN | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. |
Sequence Annotation | REPEAT 320 359 WD 1.
REPEAT 364 403 WD 2.
REPEAT 406 445 WD 3.
REPEAT 447 484 WD 4.
REPEAT 486 525 WD 5.
REPEAT 532 573 WD 6.
REPEAT 575 607 WD 7.
MOD_RES 269 269 Phosphoserine (By similarity).
MOD_RES 287 287 Phosphoserine (By similarity).
MOD_RES 289 289 Phosphoserine. |
Keyword | Alternative splicing; Autophagy; Coiled coil; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Protein transport; Reference proteome; Repeat; Transport; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 607 AA |
Protein Sequence | MSSGLRAADF PRWKRHIAEE LRRRDRLQRQ AFEEIILQYT KLLEKSDLHS VLTQKLQAEK 60
HDMPNRHEIS PGHDGAWNDS QLQEMAQLRI KHQEELTELH KKRGELAQLV IDLNNQMQQK 120
DKEIQMNEAK ISEYLQTISD LETNCLDLRT KLQDLEVANQ TLKDEYDALQ ITFTALEEKL 180
RKTTEENQEL VTRWMAEKAQ EANRLNAENE KDSRRRQARL QKELAEAAKE PLPVEQDDDI 240
EVIVDETSDH TEETSPVRAV SRAATKRLSQ PAGGLLDSIT NIFGRRSVSS IPVPQDIMDT 300
HPASGKDVRV PTTASYVFDA HDGEVNAVQF SPGSRLLATG GMDRRVKLWE AFGDKCEFKG 360
SLSGSNAGIT SIEFDSAGAY LLAASNDFAS RIWTVDDYRL RHTLTGHSGK VLSAKFLLDN 420
ARIVSGSHDR TLKLWDLRSK VCIKTVFAGS SCNDIVCTEQ CVMSGHFDKK IRFWDIRSES 480
VVREMELLGK ITALDLNPER TELLSCSRDD LLKVIDLRTN AVKQTFSAPG FKCGSDWTRV 540
VFSPDGSYVA AGSAEGSLYV WSVLTGKVEK VLSKQHSSSI NAVAWAPSGL HVVSVDKGSR 600
AVLWAQP 607 |
Gene Ontology | GO:0000421; C:autophagic vacuole membrane; IDA:MGI. GO:0034045; C:pre-autophagosomal structure membrane; IEA:UniProtKB-SubCell. GO:0000045; P:autophagic vacuole assembly; TAS:MGI. GO:0015031; P:protein transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |